| [1] | Juliano RL, Ling V (1976) A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutants. Biochim Biophys Acta 455: 152–162.
|
| [2] | Cole SP, Bhardwaj G, Gerlach JH, Mackie JE, Grant CE, et al. (1992) Overexpression of a transporter gene in a multidrug-resistant human lung cancer cell line. Science 258: 1650–1654.
|
| [3] | Leslie EM, Deeley RG, Cole SP (2005) Multidrug resistance proteins: role of P-glycoprotein, MRP1, MRP2, and BCRP (ABCG2) in tissue defense. Toxicol Appl Pharmacol 204: 216–237.
|
| [4] | Thiebaut F, Tsuruo T, Hamada H, Gottesman MM, Pastan I, et al. (1987) Cellular localization of the multidrug-resistance gene product P-glycoprotein in normal human tissues. Proc Natl Acad Sci U S A 84: 7735–7738.
|
| [5] | Cordon-Cardo C, O'Brien JP, Casals D, Rittman-Grauer L, Biedler JL, et al. (1989) Multidrug-resistance gene (P-glycoprotein) is expressed by endothelial cells at blood-brain barrier sites. Proc Natl Acad Sci U S A 86: 695–698.
|
| [6] | Flens MJ, Zaman GJ, van der Valk P, Izquierdo MA, Schroeijers AB, et al. (1996) Tissue distribution of the multidrug resistance protein. Am J Pathol 148: 1237–1247.
|
| [7] | Chen Y, Simon SM (2000) In situ biochemical demonstration that P-glycoprotein is a drug efflux pump with broad specificity. J Cell Biol 148: 863–870.
|
| [8] | Bakos E, Homolya L (2007) Portrait of multifaceted transporter, the multidrug resistance-associated protein 1 (MRP1/ABCC1). Pflugers Arch 453: 621–641.
|
| [9] | Steinke A, Meier-Stiegen S, Drenckhahn D, Asan E (2008) Molecular composition of tight and adherens junctions in the rat olfactory epithelium and fila. Histochem Cell Biol 130: 339–361.
|
| [10] | Nef P, Heldman J, Lazard D, Margalit T, Jaye M, et al. (1989) Olfactory-specific cytochrome P-450. cDNA cloning of a novel neuroepithelial enzyme possibly involved in chemoreception. J Biol Chem 264: 6780–6785.
|
| [11] | Thornton-Manning JR, Dahl AR (1997) Metabolic capacity of nasal tissue interspecies comparisons of xenobiotic-metabolizing enzymes. Mutat Res 380: 43–59.
|
| [12] | Heydel JM, Holsztynska EJ, Legendre A, Thiebaud N, Artur Y, et al. (2010) UDP-glucuronosyltransferases (UGTs) in neuro-olfactory tissues: expression, regulation, and function. Drug Metab Rev 42: 74–97.
|
| [13] | Wioland MA, Fleury-Feith J, Corlieu P, Commo F, Monceaux G, et al. (2000) CFTR, MDR1, and MRP1 immunolocalization in normal human nasal respiratory mucosa. J Histochem Cytochem 48: 1215–1222.
|
| [14] | Genter MB, Krishan M, Augustine LM, Cherrington NJ (2010) Drug transporter expression and localization in rat nasal respiratory and olfactory mucosa and olfactory bulb. Drug Metab Dispos 38: 1644–1647.
|
| [15] | Kleene SJ (2008) The electrochemical basis of odor transduction in vertebrate olfactory cilia. Chem Senses 33: 839–859.
|
| [16] | Reisert J, Zhao H (2011) Perspectives on: information and coding in mammalian sensory physiology: response kinetics of olfactory receptor neurons and the implications in olfactory coding. J Gen Physiol 138: 303–310.
|
| [17] | Graff CL, Pollack GM (2005) Functional evidence for P-glycoprotein at the nose-brain barrier. Pharm Res 22: 86–93.
|
| [18] | Kandimalla KK, Donovan MD (2005) Localization and differential activity of P-glycoprotein in the bovine olfactory and nasal respiratory mucosae. Pharm Res 22: 1121–1128.
|
| [19] | Kudo H, Doi Y, Fujimoto S (2010) Expressions of the multidrug resistance-related proteins in the rat olfactory epithelium: a possible role in the phase III xenobiotic metabolizing function. Neurosci Lett 468: 98–101.
|
| [20] | Thiebaud N, Sigoillot M, Chevalier J, Artur Y, Heydel JM, et al. (2010) Effects of typical inducers on olfactory xenobiotic-metabolizing enzyme, transporter, and transcription factor expression in rats. Drug Metab Dispos 38: 1865–1875.
|
| [21] | Manzini I, Schild D (2003) Multidrug resistance transporters in the olfactory receptor neurons of Xenopus laevis tadpoles. J Physiol 546: 375–385.
|
| [22] | Hollo Z, Homolya L, Davis CW, Sarkadi B (1994) Calcein accumulation as a fluorometric functional assay of the multidrug transporter. Biochim Biophys Acta 1191: 384–388.
|
| [23] | Feller N, Broxterman HJ, Wahrer DC, Pinedo HM (1995) ATP-dependent efflux of calcein by the multidrug resistance protein (MRP): no inhibition by intracellular glutathione depletion. FEBS Lett 368: 385–388.
|
| [24] | Chen S, Lane AP, Bock R, Leinders-Zufall T, Zufall F (2000) Blocking adenylyl cyclase inhibits olfactory generator currents induced by “IP(3)-odors”. J Neurophysiol 84: 575–580.
|
| [25] | Motulsky H (2010) Intuitive Biostatistics. USA: Oxford University Press. pp. 237–240.
|
| [26] | Feller N, Kuiper CM, Lankelma J, Ruhdal JK, Scheper RJ, et al. (1995) Functional detection of MDR1/P170 and MRP/P190-mediated multidrug resistance in tumour cells by flow cytometry. Br J Cancer 72: 543–549.
|
| [27] | Dogan AL, Legrand O, Faussat AM, Perrot JY, Marie JP (2004) Evaluation and comparison of MRP1 activity with three fluorescent dyes and three modulators in leukemic cell lines. Leuk Res 28: 619–622.
|
| [28] | Jakob I, Hauser IA, Thevenod F, Lindemann B (1998) MDR1 in taste buds of rat vallate papilla: functional, immunohistochemical, and biochemical evidence. Am J Physiol 274: C182–191.
|
| [29] | Rautio J, Humphreys JE, Webster LO, Balakrishnan A, Keogh JP, et al. (2006) In vitro p-glycoprotein inhibition assays for assessment of clinical drug interaction potential of new drug candidates: a recommendation for probe substrates. Drug Metab Dispos 34: 786–792.
|
| [30] | Lebedeva IV, Pande P, Patton WF (2011) Sensitive and specific fluorescent probes for functional analysis of the three major types of mammalian ABC transporters. PLoS One 6: e22429.
|
| [31] | Gekeler V, Ise W, Sanders KH, Ulrich WR, Beck J (1995) The leukotriene LTD4 receptor antagonist MK571 specifically modulates MRP associated multidrug resistance. Biochem Biophys Res Commun 208: 345–352.
|
| [32] | Gollapudi S, Kim CH, Tran BN, Sangha S, Gupta S (1997) Probenecid reverses multidrug resistance in multidrug resistance-associated protein-overexpressing HL60/AR and H69/AR cells but not in P-glycoprotein-overexpressing HL60/Tax and P388/ADR cells. Cancer Chemother Pharmacol 40: 150–158.
|
| [33] | Thiebaud N, Menetrier F, Belloir C, Minn AL, Neiers F, et al. (2011) Expression and differential localization of xenobiotic transporters in the rat olfactory neuro-epithelium. Neurosci Lett 505: 180–185.
|
| [34] | McAleer MA, Breen MA, White NL, Matthews N (1999) pABC11 (also known as MOAT-C and MRP5), a member of the ABC family of proteins, has anion transporter activity but does not confer multidrug resistance when overexpressed in human embryonic kidney 293 cells. J Biol Chem 274: 23541–23548.
|
| [35] | Mayer U, Kuller A, Daiber PC, Neudorf I, Warnken U, et al. (2009) The proteome of rat olfactory sensory cilia. Proteomics 9: 322–334.
|
| [36] | Thiebaut F, Tsuruo T, Hamada H, Gottesman MM, Pastan I, et al. (1989) Immunohistochemical localization in normal tissues of different epitopes in the multidrug transport protein P170: evidence for localization in brain capillaries and crossreactivity of one antibody with a muscle protein. J Histochem Cytochem 37: 159–164.
|
| [37] | Cordon-Cardo C, O'Brien JP, Boccia J, Casals D, Bertino JR, et al. (1990) Expression of the multidrug resistance gene product (P-glycoprotein) in human normal and tumor tissues. J Histochem Cytochem 38: 1277–1287.
|
| [38] | Volk H, Potschka H, Loscher W (2005) Immunohistochemical localization of P-glycoprotein in rat brain and detection of its increased expression by seizures are sensitive to fixation and staining variables. J Histochem Cytochem 53: 517–531.
|
| [39] | Hirrlinger J, Konig J, Dringen R (2002) Expression of mRNAs of multidrug resistance proteins (Mrps) in cultured rat astrocytes, oligodendrocytes, microglial cells and neurones. J Neurochem 82: 716–719.
|
| [40] | Falcao AS, Bellarosa C, Fernandes A, Brito MA, Silva RF, et al. (2007) Role of multidrug resistance-associated protein 1 expression in the in vitro susceptibility of rat nerve cell to unconjugated bilirubin. Neuroscience 144: 878–888.
|
| [41] | Karssen AM, Meijer O, Pons D, De Kloet ER (2004) Localization of mRNA expression of P-glycoprotein at the blood-brain barrier and in the hippocampus. Ann N Y Acad Sci 1032: 308–311.
|
| [42] | Volk HA, Burkhardt K, Potschka H, Chen J, Becker A, et al. (2004) Neuronal expression of the drug efflux transporter P-glycoprotein in the rat hippocampus after limbic seizures. Neuroscience 123: 751–759.
|
| [43] | Strotmann J, Breer H (1991) Generation of monoclonal antibodies detecting specific epitopes in olfactory and respiratory epithelia. Cell Tissue Res 266: 247–258.
|
| [44] | Schiengold M, Schwantes L, Schwartsmann G, Chies JA, Nardi NB (2001) Multidrug resistance gene expression during the murine ontogeny. Mech Ageing Dev 122: 255–270.
|
| [45] | Tsai CE, Daood MJ, Lane RH, Hansen TW, Gruetzmacher EM, et al. (2002) P-glycoprotein expression in mouse brain increases with maturation. Biol Neonate 81: 58–64.
|
| [46] | Rosati A, Maniori S, Decorti G, Candussio L, Giraldi T, et al. (2003) Physiological regulation of P-glycoprotein, MRP1, MRP2 and cytochrome P450 3A2 during rat ontogeny. Dev Growth Differ 45: 377–387.
|
| [47] | Leinders-Zufall T, Rand MN, Shepherd GM, Greer CA, Zufall F (1997) Calcium entry through cyclic nucleotide-gated channels in individual cilia of olfactory receptor cells: spatiotemporal dynamics. J Neurosci 17: 4136–4148.
|
| [48] | Gautam SH, Otsuguro KI, Ito S, Saito T, Habara Y (2007) T-type Ca2+ channels mediate propagation of odor-induced Ca2+ transients in rat olfactory receptor neurons. Neuroscience 144: 702–713.
|
| [49] | Safa AR (1988) Photoaffinity labeling of the multidrug-resistance-related P-glycoprotein with photoactive analogs of verapamil. Proc Natl Acad Sci U S A 85: 7187–7191.
|
| [50] | Foxwell BM, Mackie A, Ling V, Ryffel B (1989) Identification of the multidrug resistance-related P-glycoprotein as a cyclosporine binding protein. Mol Pharmacol 36: 543–546.
|
| [51] | Broxterman HJ, Pinedo HM, Schuurhuis GJ, Lankelma J (1990) Cyclosporin A and verapamil have different effects on energy metabolism in multidrug-resistant tumour cells. Br J Cancer 62: 85–88.
|
| [52] | Litman T, Skovsgaard T, Stein WD (2003) Pumping of drugs by P-glycoprotein: a two-step process? J Pharmacol Exp Ther 307: 846–853.
|
| [53] | Xie M, Rich TC, Scheitrum C, Conti M, Richter W (2011) Inactivation of multidrug resistance proteins disrupts both cellular extrusion and intracellular degradation of cAMP. Mol Pharmacol 80: 281–293.
|
| [54] | Jedlitschky G, Burchell B, Keppler D (2000) The multidrug resistance protein 5 functions as an ATP-dependent export pump for cyclic nucleotides. J Biol Chem 275: 30069–30074.
|
| [55] | Wielinga PR, van der Heijden I, Reid G, Beijnen JH, Wijnholds J, et al. (2003) Characterization of the MRP4- and MRP5-mediated transport of cyclic nucleotides from intact cells. J Biol Chem 278: 17664–17671.
|
| [56] | Cygnar KD, Zhao H (2009) Phosphodiesterase 1C is dispensable for rapid response termination of olfactory sensory neurons. Nat Neurosci 12: 454–462.
|
| [57] | Firestein S, Darrow B, Shepherd GM (1991) Activation of the sensory current in salamander olfactory receptor neurons depends on a G protein-mediated cAMP second messenger system. Neuron 6: 825–835.
|
| [58] | Reid G, Wielinga P, Zelcer N, De Haas M, Van Deemter L, et al. (2003) Characterization of the transport of nucleoside analog drugs by the human multidrug resistance proteins MRP4 and MRP5. Mol Pharmacol 63: 1094–1103.
|
| [59] | Matthews HR, Reisert J (2003) Calcium, the two-faced messenger of olfactory transduction and adaptation. Curr Opin Neurobiol 13: 469–475.
|
| [60] | Hegg CC, Greenwood D, Huang W, Han P, Lucero MT (2003) Activation of purinergic receptor subtypes modulates odor sensitivity. J Neurosci 23: 8291–8301.
|
| [61] | Buss DS, Callaghan A (2008) Interaction of pesticides with p-glycoprotein and other ABC proteins: A survey of the possible importance to insecticide, herbicide and fungicide resistance. Pesticide Biochemistry and Physiology 90: 141–153.
|
| [62] | Hall RA (2011) Autonomic modulation of olfactory signaling. Sci Signal 4: pe1.
|
| [63] | Kawai F, Kurahashi T, Kaneko A (1999) Adrenaline enhances odorant contrast by modulating signal encoding in olfactory receptor cells. Nat Neurosci 2: 133–138.
|
| [64] | Costa VM, Ferreira LM, Branco PS, Carvalho F, Bastos ML, et al. (2009) Cross-functioning between the extraneuronal monoamine transporter and multidrug resistance protein 1 in the uptake of adrenaline and export of 5-(glutathion-S-yl)adrenaline in rat cardiomyocytes. Chem Res Toxicol 22: 129–135.
|
