| [1] | Scholey JM (1996) Kinesin-II, a membrane traffic motor in axons, axonemes, and spindles. J Cell Biol 133: 1–4.
|
| [2] | Hirokawa N (1998) Kinesin and dynein superfamily proteins and the mechanism of organelle transport. Science 279: 519–526.
|
| [3] | Yang JT, Laymon RA, Goldstein LS (1989) A three-domain structure of kinesin heavy chain revealed by DNA sequence and microtubule binding analyses. Cell 56: 879–889.
|
| [4] | Vale RD (2003) The molecular motor toolbox for intracellular transport. Cell 112: 467–480.
|
| [5] | Hua W, Chung J, Gelles J (2002) Distinguishing inchworm and hand-over-hand processive kinesin movement by neck rotation measurements. Science 295: 844–848.
|
| [6] | Asbury CL, Fehr AN, Block SM (2003) Kinesin moves by an asymmetric hand-over-hand mechanism. Science 302: 2130–2134.
|
| [7] | Kaseda K, Higuchi H, Hirose K (2003) Alternate fast and slow stepping of a heterodimeric kinesin molecule. Nat Cell Biol 5: 1079–1082.
|
| [8] | Yildiz A, Tomishige M, Vale RD, Selvin PR (2004) Kinesin walks hand-over-hand. Science 303: 676–678.
|
| [9] | Rice S, Lin AW, Safer D, Hart CL, Naber N, et al. (1999) A structural change in the kinesin motor protein that drives motility. Nature 402: 778–784.
|
| [10] | Wade RH, Kozielski F (2000) Structural links to kinesin directionality and movement. Nat Struct Biol 7: 456–460.
|
| [11] | Miyazono Y, Hayashi M, Karagiannis P, Harada Y, Tadakuma H (2010) Strain through the neck linker ensures processive runs: a DNA-kinesin hybrid nanomachine study. EMBO J 29: 93–106.
|
| [12] | Shastry S, Hancock WO (2010) Neck linker length determines the degree of processivity in kinesin-1 and kinesin-2 motors. Curr Biol 20: 939–943.
|
| [13] | Hwang W, Lang MJ, Karplus M (2008) Force generation in kinesin hinges on cover-neck bundle formation. Structure 16: 62–71.
|
| [14] | Vale RD, Milligan RA (2000) The way things move: looking under the hood of molecular motor proteins. Science 288: 88–95.
|
| [15] | Xie P (2010) Mechanism of processive movement of monomeric and dimeric kinesin molecules. Int J Biol Sci 6: 665–674.
|
| [16] | Kutys ML, Fricks J, Hancock WO (2010) Monte Carlo analysis of neck linker extension in kinesin molecular motors. PLoS Comput Biol 6: e1000980.
|
| [17] | Howard J (1996) The movement of kinesin along microtubules. Annu Rev Physiol 58: 703–729.
|
| [18] | Walker RA, Salmon ED, Endow SA (1990) The Drosophila claret segregation protein is a minus-end directed motor molecule. Nature 347: 780–782.
|
| [19] | Endow SA, Kang SJ, Satterwhite LL, Rose MD, Skeen VP, et al. (1994) Yeast Kar3 is a minus-end microtubule motor protein that destabilizes microtubules preferentially at the minus ends. EMBO J 13: 2708–2713.
|
| [20] | Sablin EP, Kull FJ, Cooke R, Vale RD, Fletterick RJ (1996) Crystal structure of the motor domain of the kinesin-related motor ncd. Nature 380: 555–559.
|
| [21] | Sablin EP, Case RB, Dai SC, Hart CL, Ruby A, et al. (1998) Direction determination in the minus-end-directed kinesin motor ncd. Nature 395: 813–816.
|
| [22] | Sosa H, Dias DP, Hoenger A, Whittaker M, Wilson-Kubalek E, et al. (1997) A model for the microtubule-Ncd motor protein complex obtained by cryo-electron microscopy and image analysis. Cell 90: 217–224.
|
| [23] | Hirose K, Cross RA, Amos LA (1998) Nucleotide-dependent structural changes in dimeric NCD molecules complexed to microtubules. J Mol Biol 278: 389–400.
|
| [24] | Wendt TG, Volkmann N, Skiniotis G, Goldie KN, Muller J, et al. (2002) Microscopic evidence for a minus-end-directed power stroke in the kinesin motor ncd. EMBO Journal 21: 5969–5978.
|
| [25] | Endres NF, Yoshioka C, Milligan RA, Vale RD (2006) A lever-arm rotation drives motility of the minus-end-directed kinesin Ncd. Nature 439: 875–878.
|
| [26] | Kozielski F, De Bonis S, Burmeister WP, Cohen-Addad C, Wade RH (1999) The crystal structure of the minus-end-directed microtubule motor protein ncd reveals variable dimer conformations. Structure 7: 1407–1416.
|
| [27] | Yun M, Bronner CE, Park CG, Cha SS, Park HW, et al. (2003) Rotation of the stalk/neck and one head in a new crystal structure of the kinesin motor protein, Ncd. EMBO J 22: 5382–5389.
|
| [28] | Cross RA (2010) Kinesin-14: the roots of reversal. BMC Biol 8: 107.
|
| [29] | Heuston E, Bronner CE, Kull FJ, Endow SA (2010) A kinesin motor in a force-producing conformation. BMC Struct Biol 10: 19.
|
| [30] | Page BD, Satterwhite LL, Rose MD, Snyder M (1994) Localization of the Kar3 kinesin heavy chain-related protein requires the Cik1 interacting protein. J Cell Biol 124: 507–519.
|
| [31] | Manning BD, Barrett JG, Wallace JA, Granok H, Snyder M (1999) Differential regulation of the Kar3p kinesin-related protein by two associated proteins, Cik1p and Vik1p. J Cell Biol 144: 1219–1233.
|
| [32] | Barrett JG, Manning BD, Snyder M (2000) The Kar3p kinesin-related protein forms a novel heterodimeric structure with its associated protein Cik1p. Mol Biol Cell 11: 2373–2385.
|
| [33] | Manning BD, Snyder M (2000) Drivers and passengers wanted! the role of kinesin-associated proteins. Trends Cell Biol 10: 281–289.
|
| [34] | Chu HM, Yun M, Anderson DE, Sage H, Park HW, et al. (2005) Kar3 interaction with Cik1 alters motor structure and function. EMBO J 24: 3214–3223.
|
| [35] | Sproul LR, Anderson DJ, Mackey AT, Saunders WS, Gilbert SP (2005) Cik1 targets the minus-end kinesin depolymerase kar3 to microtubule plus ends. Curr Biol 15: 1420–1427.
|
| [36] | Allingham J, Sproul L, Rayment I, Gilbert S (2007) Vik1 Modulates Microtubule-Kar3 Interactions through a Motor Domain that Lacks an Active Site. Cell 128: 1161–1172.
|
| [37] | Gulick AM, Song H, Endow SA, Rayment I (1998) X-ray crystal structure of the yeast Kar3 motor domain complexed with Mg.ADP to 2.3 A resolution. Biochemistry 37: 1769–1776.
|
| [38] | Woehlke G, Schliwa M (2007) Kinesin Kar3 and Vik1 Go Head to Head. Cell 128: 1033–1034.
|
| [39] | Xie P, Dou SX, Wang PY (2007) Limping of homodimeric kinesin motors. J Mol Biol 366: 976–985.
|
| [40] | Hou R, Wang Z (2010) A coordinated molecular ‘fishing’ mechanism in heterodimeric kinesin. Physical Biology 7: 036003.
|
| [41] | Cai D, Hoppe AD, Swanson JA, Verhey KJ (2007) Kinesin-1 structural organization and conformational changes revealed by FRET stoichiometry in live cells. J Cell Biol 176: 51–63.
|
| [42] | Evans E, Ritchie K (1997) Dynamic strength of molecular adhesion bonds. Biophys J 72: 1541–1555.
|
| [43] | Rief M, Pascual J, Saraste M, Gaub HE (1999) Single molecule force spectroscopy of spectrin repeats: low unfolding forces in helix bundles. J Mol Biol 286: 553–561.
|
| [44] | Paci E, Karplus M (2000) Unfolding proteins by external forces and temperature: the importance of topology and energetics. Proc Natl Acad Sci U S A 97: 6521–6526.
|
| [45] | Essevaz-Roulet B, Bockelmann U, Heslot F (1997) Mechanical separation of the complementary strands of DNA. Proc Natl Acad Sci U S A 94: 11935–11940.
|
| [46] | Uemura S, Kawaguchi K, Yajima J, Edamatsu M, Toyoshima YY, et al. (2002) Kinesin-microtubule binding depends on both nucleotide state and loading direction. Proc Natl Acad Sci U S A 99: 5977–5981.
|
| [47] | Bornschlogl T, Woehlke G, Rief M (2009) Single molecule mechanics of the kinesin neck. Proc Natl Acad Sci U S A 106: 6992–6997.
|
| [48] | Tomishige M, Vale RD (2000) Controlling kinesin by reversible disulfide cross-linking. Identifying the motility-producing conformational change. J Cell Biol 151: 1081–1092.
|
| [49] | Mason JM, Arndt KM (2004) Coiled coil domains: stability, specificity, and biological implications. Chembiochem 5: 170–176.
|
| [50] | Thormahlen M, Marx A, Sack S, Mandelkow E (1998) The coiled-coil helix in the neck of kinesin. J Struct Biol 122: 30–41.
|
| [51] | Tripet B, Hodges RS (2002) Helix capping interactions stabilize the N-terminus of the kinesin neck coiled-coil. J Struct Biol 137: 220–235.
|
| [52] | Ito M, Morii H, Shimizu T, Tanokura M (2006) Coiled coil in the stalk region of ncd motor protein is nonlocally sustained. Biochemistry 45: 3315–3324.
|
| [53] | Hackney DD (1994) Evidence for alternating head catalysis by kinesin during microtubule-stimulated ATP hydrolysis. Proc Natl Acad Sci U S A 91: 6865–6869.
|
| [54] | Alonso MC, Drummond DR, Kain S, Hoeng J, Amos L, et al. (2007) An ATP gate controls tubulin binding by the tethered head of kinesin-1. Science 316: 120–123.
|
| [55] | Xie P (2008) Stepping behavior of two-headed kinesin motors. Biochim Biophys Acta 1777: 1195–1202.
|
| [56] | Altman D, Sweeney HL, Spudich JA (2004) The mechanism of myosin VI translocation and its load-induced anchoring. Cell 116: 737–749.
|
| [57] | Xie P, Dou SX, Wang PY (2006) A hand-over-hand diffusing model for myosin-VI molecular motors. Biophys Chem 122: 90–100.
|
| [58] | Kozielski F (1997) The Crystal Structure of Dimeric Kinesin and Implications for Microtubule-Dependent Motility. Cell 91:
|
| [59] | Kumar S, Bouzida D, Swendsen RH, Kollman PA, Rosenberg JM (1992) The Weighted Histogram Analysis Method for Free-Energy Calculations on Biomolecules .1. The Method. Journal of Computational Chemistry 13: 1011–1021.
|
| [60] | Bartels C (2000) Analyzing biased Monte Carlo and molecular dynamics simulations. Chemical Physics Letters 331: 446–454.
|
