Stromal Cell-derived Factor (SDF-1 β) Gene Single Nucleotide Polymorphism at Position G801A is Associated with Type 2 Diabetes Mellitus in a South Indian Population

In this case-control study, we investigated the association of G801A single nucleotide polymorphisms (SNPs) in the SDF-1β gene (SDF-1β 3’A) with type 2 diabetes (T2DM) in a south Indian population. In this assessment, peripheral blood samples were collected from 150 T2DM patients and 150 healthy controls who attended our tertiary care hospital in Chennai, India. Peripheral blood genomic DNA was extracted and subjected to PCR-RFLP, to examine SDF-1β gene polymorphism. Our results showed that the genotype frequency of “GG” was significantly associated with T2DM when compared to healthy controls (P <0.001). Interestingly, our results also showed that SDF-1 “G” allele to be risk allele [1.238 (0.899-1.706)] and “A” to be the protective allele for T2DM at least in our south Indian population. Based on the results of this study, we conclude that SDF-1β 3’A polymorphism to play a role in the pathogenesis of T2DM.