Quatitative Methods for the Identification of Cefuroxime Sodium

From this study, methods for quantitative analysis were developed to determine cefuroxime sodium in the raw material and in pharmaceutical formulations. These tests included instrumental methods such as spectrophotometry in the ultraviolet, visible and infrared, high performance liquid chromatography and potentiometric determination by microbiological methods (agar diffusion and turbidimetric). The concentration range determined for each method varied greatly, which increases the usability of cefuroxime fori dentifying quality control. In spectrophotometric methods cefuroxime was determined from 5.0μg/ml to 2.0mg/mL.The microbiological methods have determined the drug concentration 30.0-120.0 μg/ml and HPLC ranged from 10.0to15.0μg/ml.The results obtained by analysis of the dosage form were compared to results obtained by analysis of the reference substance and showed significance. These methods proved to be reproducible and rapid determination of cefuroxime can be routinely used in quality control analysis.