Humphrey Matrix Perimetry for Open-Angle Glaucoma Screening in A High-Risk Population

The aim of this study was to evaluate the role of Humphrey Matrix perimetry to better guide appropriate referral of at-risk individuals for glaucoma assessment. Fifty-two consecutive patients referred to a specialist glaucoma ophthalmology practice for an opinion about a new diagnosis of glaucoma were enrolled. Prior to assessment for presence of open-angle glaucoma, patients performed Humphrey Matrix perimetry with results withheld from both patient and assessing glaucoma specialist. Humphrey Matrix perimetry results were later compared with the outcome of clinical assessment for each individual. Eleven of 52 participants were diagnosed with open-angle glaucoma (21.2%). Negative predictive value of Humphrey Matrix perimetry in this population ranged from 87.1% to 93.6% depending on the indices used. Only two individuals with normal Humphrey Matrix perimetry were diagnosed with open-angle glaucoma. These results suggest Humphrey Matrix perimetry displays a high negative predictive value when screening for open-angle glaucoma in an at-risk population. It may be useful in this context to better guide eye health professionals on appropriate referral of patients for an opinion about glaucoma.