Effects of Parinari Polyandra Seed Extract on Blood Glucose Level and Biochemical indices in Wistar Rats

In light of traditional anti-diabetic claim, therapeutic effect of coconut water extract of Parinari polyandra seeds on fasting blood sugar level and serum biochemical indices in alloxan-induced diabetic rats was investigated. Ten normoglycemic and forty diabetic rats (randomly assigned to four groups, n=10) (mean weight of 222±13.01g) were used for the study. The normoglycemic rats (group1) served as normal control and a group of diabetic rats (group II) served as diabetic control. Other groups of diabetic rats (Group III, IV and V) were treated differently with (1) coconut water extract of Parinari polyandra seeds (2ml), coconut water alone (2ml) and (3) Glibenclamide, a standard antidiabetic drug (5mg/Kg of body weight). The treatments were done orally for seven days. Blood glucose level, aspartate aminotransferase (AST) and alanine aminotransferase (ALT) activities, total cholesterol, total triglyceride(TG), low density lipoprotein (LDL) and high density lipoprotein (HDL) were examined. The results obtained revealed that rats treated with Parinari polyandra seeds extract expressed significant (p≤0.05) decrease in the levels of glucose, ALT, AST, TAG, total cholesterol, LDL with slight increase in HDL as compared with diabetic control rats. Collectively, the data of the current study indicates that coconut water extract of Parinari polyandra has antidiabetic, anti-hyperlipidemia and anticholesterolemia potentials. Hence, its local use in the management of diabetes should be encouraged.