Immunomodulatory Activity of Methanolic Extracts of Ficus Glomerata Roxb. Leaf, Fruit and Bark in Cyclophosphamide Induced Mice

To evaluate the immunomodulatory activity of methanolic extracts of Ficus glomerata Roxb. leaves, fruits and bark on cyclophosphamide induced immunosuppression in mice. Methanolic extracts of leaves, fruits and bark of Ficus glomerata Roxb. (500mg/kg p.o.) were administered 13 days to albino mice and cyclophosphamide (30mg/kg i.p.) was administered on 11th,12th and 13th days 1 hour after the administration of the respective treatment. On the 14th day blood was collected by retro orbital puncture and the activity was evaluated by determining the RBC, Hb%, Platelet, total WBC and differential counts. Methanolic extracts of leaves, fruits & bark of Ficus glomerata Roxb. showed very significant (p<0.001) counteracting effect to cyclophosphamide induced reduction in total WBC, DLC and platelet counts & significant (P<0.01) effect to that of reduction in RBC counts and Hb %. The significant inmmunostimulant effect of the methanolic extracts of Ficus glomerata Roxb. leaf, fruit & barks on cyclophosphamide induced myelosuppression may be attributed towards the collective presence of saponins, sterols and tannins in the extracts, which suggest the immunomodulatory activities of the methanolic extracts of Ficus glomerata Roxb. leaves, fruits & bark.