The effects of daily chlorhexidine bathing on cutaneous bacterial isolates: a pilot study

ts of daily chlorhexidine bathing on cutaneous bacterial isolates: a pilot study Rapid Communication (2378) Total Article Views Authors: Soma VL, Qin X, Zhou C, Adler A, Berry JE, Zerr DM Published Date April 2012 Volume 2012:5 Pages 75 - 78 DOI: http://dx.doi.org/10.2147/IDR.S30662 Received: 08 February 2012 Accepted: 28 February 2012 Published: 24 April 2012 Vijaya L Soma1, Xuan Qin2, Chuan Zhou1, Amanda Adler1, Jessica E Berry2, Danielle M Zerr1 1Department of Pediatrics, 2Department of Laboratory Medicine, University of Washington, Seattle, WA, USA Abstract: Chlorhexidine gluconate (CHG) is a topical antiseptic used in a myriad of clinical settings. Recently, CHG baths have been shown to decrease multidrug-resistant organism acquisition and infections and catheter-associated bloodstream infections. The present study examined the effects of daily bathing with CHG on the recovery and antimicrobial susceptibility of cultivable cutaneous bacteria. The objectives of this study were to (1) explore the effects of clinical CHG bathing on cultivable cutaneous bacteria, (2) study the relationship between CHG minimum inhibitory concentration and antimicrobial susceptibility of coagulase-negative staphylococci, and (3) demonstrate the feasibility of the approach so a more definitive study may be performed. Significant decreases in bacterial colony counts and phenotypic diversity occurred with greater CHG exposure. The findings also suggest an inverse relationship between CHG minimum inhibitory concentration and antimicrobial susceptibility. Larger prospective studies are necessary to fully investigate the clinical impact of CHG usage.