Indacaterol improves daily physical activity in patients with chronic obstructive pulmonary disease

dacaterol improves daily physical activity in patients with chronic obstructive pulmonary disease Original Research (1923) Total Article Views Authors: Hataji O, Naito M, Ito K, Watanabe F, Gabazza EC, Taguchi O Published Date December 2012 Volume 2013:8 Pages 1 - 5 DOI: http://dx.doi.org/10.2147/COPD.S38548 Received: 26 September 2012 Accepted: 19 November 2012 Published: 28 December 2012 Osamu Hataji,1 Masahiro Naito,1 Kentaro Ito,1 Fumiaki Watanabe,1 Esteban C Gabazza,2 Osamu Taguchi3 1Respiratory Center, Matsusaka Municipal Hospital, Tonomachi, 2Department of Immunology, 3Department of Pulmonary and Critical Care Medicine, Mie University Graduate School of Medicine, Mie, Japan Background: The current mainstay of therapy for chronic obstructive pulmonary disease (COPD) is long-acting bronchodilators. To date, the effect of indacaterol, a β2-agonist, on activities of daily living in COPD patients is not well understood. The aim of this study was to evaluate the efficacy of indacaterol with regard to activities of daily living in patients with COPD. Methods: In this nonrandomized open-label study, 23 patients with COPD were instructed to carry an accelerometer for 4 weeks without indacaterol therapy and then for another period of 4 weeks while receiving indacaterol therapy. Results: The number of steps, duration of moderate or greater physical activity, and energy expenditure were significantly increased after treatment with indacaterol compared with baseline data in all patients with COPD; the metabolic equivalent of task was also significantly enhanced after treatment with indacaterol. Conclusion: This study provides early evidence that indacaterol improves daily physical activity in patients with COPD.