Improvement in Central Pontine Myelinosis with IV immunoglobulin

Improvement in Central Pontine Myelinosis with IV immunoglobulin Case report (616) Total Article Views Authors: Ramos VF, Filho JA, Antony AR, Helvey JT, Bertoni J Published Date April 2012 Volume 2012:2 Pages 24 - 26 DOI: http://dx.doi.org/10.2147/JPRLS.S37078 Received: 16 August 2012 Accepted: Published: 17 August 2012 Vesper Fe Marie Llaneza Ramos,1 J Americo Fernandes Filho,1 Arun Raj Antony,1 Jason T. Helvey,2 John Bertoni1 1Department of Neurological Sciences, University of Nebraska Medical Center; 2Department of Radiology, University of Nebraska Medical Center Introduction: Central pontine myelinolysis (CPM) is a rare, serious demyelinating disease, associated with rapid correction of chronic hyponatremia, usually in the setting of alcoholism and electrolyte disturbance.1 2 Magnetic resonance imaging (MRI) is a decisive diagnostic tool for CPM.3 The pathogenesis is unknown and there is no established treatment. There have been case reports on the efficacy of intravenous immunoglobulin (IVIG).4 5 Postulated mech-anisms include reduction of myelinotoxic agents, development of antimyelin antibodies, and promotion of remyelination.4 We report a case of CPM associated with chronic alcoholism and hyponatremia, with significant clinical improvement and resolution of MRI changes after treatment with IVIG. Post to: Cannotea Citeulike Del.icio.us Facebook LinkedIn Twitter Readers of this article also read: Conivaptan: a step forward in the treatment of hyponatremia? Conivaptan: Evidence supporting its therapeutic use in hyponatremia Conivaptan and its role in the treatment of hyponatremia Fructose-enhanced reduction of bacterial growth on nanorough surfaces A case of mistaken identity: alcohol withdrawal, schizophrenia, or central pontine myelinolysis? In vitro and in vivo studies on gelatin-siloxane nanoparticles conjugated with SynB peptide to increase drug delivery to the brain Improved oral bioavailability of poorly water-soluble indirubin by a supersaturatable self-microemulsifying drug delivery system Clinical & Neuropsychological profile in patients with Parkinson’s disease and Parkinson’s Plus syndromes: study from a tertiary care referral centre in a developing country Depression in Parkinson’s disease Restless legs syndrome