A guide to interpretation of neuroimmunological biomarkers in the combined antiretroviral therapy-era of HIV central nervous system disease

guide to interpretation of neuroimmunological biomarkers in the combined antiretroviral therapy-era of HIV central nervous system disease Review (3298) Total Article Views Authors: Katrina A Morris, Nicholas WS Davies, Bruce J Brew Published Date August 2010 Volume 2010:2 Pages 59 - 72 DOI: http://dx.doi.org/10.2147/NBHIV.S7167 Katrina A Morris, Nicholas WS Davies, Bruce J Brew Department of Neurology, St. Vincent’s Hospital, Sydney, Australia and St. Vincent’s Centre for Applied Medical Research, Sydney, New South Wales, Australia Abstract: Biomarkers have emerging roles in diagnosis, prognostication, and treatment monitoring in patients with human immunodeficiency virus-related central nervous system disease. Currently, it is unlikely that a single biomarker will be able to fulfill these roles; rather a combination is more likely. In this review, we use a pathogenetic framework to discuss biomarkers derived from both the blood and cerebrospinal fluid. Emphasis is given to those biomarkers that have a more solid evidence base and those that are easily measurable.