Randomized controlled trial on the safety of intracameral cephalosporins in cataract surgery

ndomized controlled trial on the safety of intracameral cephalosporins in cataract surgery Original Research (4448) Total Article Views Authors: Philip TH Lam, Alvin L Young, Lulu L Cheng, et al Published Date December 2010 Volume 2010:4 Pages 1499 - 1504 DOI: http://dx.doi.org/10.2147/OPTH.S15602 Philip TH Lam, Alvin L Young, Lulu L Cheng, Patrick MK Tam, Vincent YW Lee Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong SAR, China Objective: To compare the safety profiles of intracameral cephalosporins in cataract surgery. Patients and methods: In this controlled trial, 129 patients were randomized to one of four groups to receive 1 mg of one of three cephalosporins – cefazolin, cefuroxime, or ceftazidime, or normal saline – given intracamerally during cataract surgery. Central endothelial cell density (ECD) and retinal center point thickness (CPT) were determined by specular microscopy and ocular coherence tomography, respectively, before and at 3 months after surgery. Results: There were no statistical significant differences in the changes of ECD and CPT between eyes receiving intracameral cephalosporin and control. Conclusion: The use of intracameral cefazolin, cefuroxime, or ceftazidime (1 mg in 0.1-mL solution) at the time of cataract surgery had no significant effect on ECD and CPT postoperatively.