Enucleation following treatment with intravenous pentamidine for Acanthamoeba sclerokeratitis

ucleation following treatment with intravenous pentamidine for Acanthamoeba sclerokeratitis Case report (4211) Total Article Views Authors: Rebecca A Kuennen, Reynell Harder Smith, Thomas F Mauger, et al Published Date September 2010 Volume 2010:4 Pages 1145 - 1149 DOI: http://dx.doi.org/10.2147/OPTH.S13831 Rebecca A Kuennen, Reynell Harder Smith, Thomas F Mauger, Elson Craig Department of Ophthalmology, The Ohio State University, Columbus, Ohio, USA Purpose: To describe the course and outcome of treatment of advanced Acanthamoeba sclerokeratitis with intravenous pentamidine. Methods: A case of advanced Acanthamoeba sclerokeratitis was resistant to conventional therapy and was treated with intravenous pentamidine. The eye was later removed due to incapacitating pain. Results: The eye showed Acanthamoeba organisms within the cornea and evidence of acute and chronic inflammation throughout the remainder of the eye. The patient has survived without orbital recurrence for 2 years. Conclusions: This case demonstrates late inflammation with active Acanthameoba keratitis following systemic pentamidine therapy.