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Relationship between grades of macular perfusion and foveal thickness in branch retinal vein occlusion

DOI: http://dx.doi.org/10.2147/OPTH.S37185

Keywords: branch retinal vein occlusion, macular perfusion, foveal thickness, macular edema

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Abstract:

tionship between grades of macular perfusion and foveal thickness in branch retinal vein occlusion Original Research (1069) Total Article Views Authors: Sakimoto S, Kamei M, Suzuki M, Yano S, Matsumura N, Sakaguchi H, Gomi F, Nishida K Published Date December 2012 Volume 2013:7 Pages 39 - 45 DOI: http://dx.doi.org/10.2147/OPTH.S37185 Received: 20 August 2012 Accepted: 01 October 2012 Published: 31 December 2012 Susumu Sakimoto, Motohiro Kamei, Mihoko Suzuki, Shinsaku Yano, Nagakazu Matsumura, Hirokazu Sakaguchi, Fumi Gomi, Kohji Nishida Department of Ophthalmology, Osaka University Graduate School of Medicine, Suita, Japan Background: To study the relationship between retinal perfusion around the macula and the foveal thickness in branch retinal vein occlusion (BRVO). Methods: Seventy-four eyes of 74 consecutive patients with BRVO were enrolled. We developed a new grading system to evaluate the status of retinal perfusion around the macula in three grades: full perfusion area (FPA), partial perfusion area (PPA), and nonperfusion area (NPA), using fluorescein angiography. The correlation was assessed between these grades and the central foveal thickness (CFT) measured by optical coherence tomography. We also determined the area with the closest correlation between the perfusion status and the foveal thickness by comparing the correlation coefficient in areas of 1-, 2-, and 3-disc diameter (DD) horizontal hemicircles centered at the fovea. The correlation was determined between the extent of each perfusion grade and CFT. Results: We found a significant negative correlation between the CFT and the FPA (r = 0.31, P = 0.006) and a significant positive correlation between the CFT and the PPA (r = 0.45, P < 0.001) in the three areas. The most significant correlations were found in the 2-DD area. Interestingly, the NPA has not correlated with the foveal thickness in any areas. Conclusion: The areas of partial but not complete capillary loss seem to be responsible for the macular edema associated with BRVO. Treatments targeting leakage from the dilated capillaries in the PPA should be investigated.

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