Evolution and adaptation of the pandemic A/H1N1 2009 influenza virus

lution and adaptation of the pandemic A/H1N1 2009 influenza virus Review (4453) Total Article Views Authors: Ducatez MF, Fabrizio TP, Webby RJ Published Date July 2011 Volume 2011:3 Pages 45 - 53 DOI: http://dx.doi.org/10.2147/VAAT.S9656 Mariette F Ducatez, Thomas P Fabrizio, Richard J Webby Department of Infectious Diseases, St Jude Children's Research Hospital, Memphis, TN, USA Abstract: The emergence of the 2009 H1N1 pandemic influenza virus [A(H1N1)pdm09] has provided the public health community with many challenges, but also the scientific community with an opportunity to monitor closely its evolution through the processes of drift and shift. To date, and despite having circulated in humans for nearly two years, little antigenic variation has been observed in the A(H1N1)pdm09 viruses. However, as the A(H1N1)pdm09 virus continues to circulate and the immunologic pressure within the human population increases, future antigenic change is almost a certainty. Several coinfections of A(H1N1)pdm09 and seasonal A(H1N1) or A(H3N2) viruses have been observed, but no reassortant viruses have been described in humans, suggesting a lack of fitness of reassortant viruses or a lack of opportunities for interaction of different viral lineages. In contrast, multiple reassortment events have been detected in swine populations between A(H1N1) pdm09 and other endemic swine viruses. Somewhat surprisingly, many of the well characterized influenza virus virulence markers appear to have limited impact on the phenotype of the A(H1N1)pdm09 viruses when they have been introduced into mutant viruses in laboratory settings. As such, it is unclear what the evolutionary path of the pandemic virus will be, but the monitoring of any changes in the circulating viruses will remain a global public and animal health priority.