Acyclovir and hydrocortisone cream for the early treatment of recurrent cold sores

cyclovir and hydrocortisone cream for the early treatment of recurrent cold sores Review (5650) Total Article Views Authors: Carrie A Sailer, Spotswood L Spruance, Christopher M Hull Published Date January 2011 Volume 2011:3 Pages 1 - 6 DOI: http://dx.doi.org/10.2147/VAAT.S7748 Carrie A Sailer1, Spotswood L Spruance2, Christopher M Hull1 1Department of Dermatology, 2Department of Medicine, Division of Infectious Diseases, University of Utah, Salt Lake City, USA Abstract: Current antiviral therapies for herpes simplex labialis primarily reduce healing time. Since the host immune response also plays a role in both controlling recurrent infection as well as producing clinical symptoms, new studies are showing efficacy using topical corticosteroids. This review will evaluate the safety and efficacy of 5% acyclovir–1% hydrocortisone cream (Xerese [US], Xerclear [Europe]) for treatment of patients with herpes simplex labialis. A large, randomized, double-blind, placebo-controlled study recently demonstrated that treatment with 5% acyclovir–1% hydrocortisone cream significantly decreased the percentage of ulcerative lesions, reduced lesion healing time, and decreased mean lesion area compared with both topical acyclovir alone and vehicle.