全部 标题 作者
关键词 摘要

OALib Journal期刊
ISSN: 2333-9721
费用:99美元

查看量下载量

相关文章

更多...
Core Evidence  2011 

Aztreonam (for inhalation solution) for the treatment of chronic lung infections in patients with cystic fibrosis: an evidence-based review

DOI: http://dx.doi.org/10.2147/CE.S11181

Keywords: cystic fibrosis, aztreonam lysine, Pseudomonas aeruginosa, inhaled antibiotics

Full-Text   Cite this paper   Add to My Lib

Abstract:

ztreonam (for inhalation solution) for the treatment of chronic lung infections in patients with cystic fibrosis: an evidence-based review Review (3850) Total Article Views Authors: Kirkby S, Novak K, McCoy K Published Date August 2011 Volume 2011:6 Pages 59 - 66 DOI: http://dx.doi.org/10.2147/CE.S11181 Stephen Kirkby1, Kimberly Novak2, Karen McCoy1 1Section of Pulmonary Medicine, Nationwide Children's Hospital, 2Department of Pharmacy, Nationwide Children's Hospital, Ohio State University College of Medicine, Columbus, OH, USA Abstract: Cystic fibrosis (CF) is a genetic disease caused by abnormal chloride transport across cellular membranes. In the respiratory tract, this molecular defect causes obstruction of the airways by mucus and chronic endobronchial infection. The majority of patients suffer early death from chronic respiratory disease. Pseudomonas aeruginosa is the predominant chronic airway pathogen in older children and adults with CF and is associated with worse outcomes. However, overall survival in CF has been greatly improved in recent decades due in large part to the aggressive treatment of chronic infections such as P. aeruginosa. While intravenous and oral antibiotics are commonly used in the management of CF respiratory infections, inhaled anti-infective therapies offer the benefit of delivering the drug directly to the site of infection and avoiding potential toxicities associated with systemic absorption. Aztreonam lysine (AZLI) has recently been developed as an inhaled antibiotic for chronic use in CF patients with endobronchial P. aeruginosa infection. This paper reviews background data and the clinical studies which contributed to AZLI's formal FDA approval and growing role in the management of CF pulmonary disease.

Full-Text

Contact Us

service@oalib.com

QQ:3279437679

WhatsApp +8615387084133