Treatment of acute otitis externa with ciprofloxacin otic 0.2% antibiotic ear solution

eatment of acute otitis externa with ciprofloxacin otic 0.2% antibiotic ear solution Review (3660) Total Article Views Authors: M sges R, Nematian-Samani M, Eichel A Published Date July 2011 Volume 2011:7 Pages 325 - 326 DOI: http://dx.doi.org/10.2147/TCRM.S6769 R M sges, M Nematian-Samani, A Eichel Institute of Medical Statistics, Informatics and Epidemiology, Faculty of Medicine, University of Cologne, Germany Background/objective: An inflammation of the cutis and subcutis of the external auditory canal is a primary symptom in cases of acute otitis externa. It is usually treated locally, since this type of therapy ensures a high concentration of the drug and interacts at the site of inflammation with no systemic effects. This systematic review compares the efficacy of treatment using a ciprofloxacin 0.2% solution with other therapeutic options. Methods: After compiling a catalog of search terms, medical databases were searched systematically for randomized, controlled studies. This search initially yielded a total of 38 studies which were then evaluated by three independent reviewers. The number of studies was subsequently reduced to 14: six studies using a ciprofloxacin 0.2% solution, and eight studies using both 0.2% and 0.3% solutions. Results: The studies included in the review demonstrate the statistical equivalence between the ciprofloxacin solution (0.2%) and the reference products PNH (a combination of polymyxin B, neomycin sulfate and hydrocortisone), auriculum powder, and a ciprofloxacin foam with respect to the cure rate. The research groups consistently observed high in vitro activity of ciprofloxacin against Pseudomonas aeruginosa. Conclusion: This systematic review confirms the hypothesis of ciprofloxacin's noninferiority in the treatment of otitis externa, in terms of the cure rate and microbiological eradication.