Cumulative clinical experience with use of insulin lispro: critical appraisal, role in therapy, and patient considerations

mulative clinical experience with use of insulin lispro: critical appraisal, role in therapy, and patient considerations Review (3027) Total Article Views Authors: Uy J, Fogelfeld L, Guerra Y Published Date January 2012 Volume 2012:5 Pages 1 - 10 DOI: http://dx.doi.org/10.2147/DMSO.S15404 Received: 26 September 2011 Accepted: 07 November 2011 Published: 10 January 2012 J Uy, L Fogelfeld, Y Guerra Division of Endocrinology, Diabetes and Metabolism, John H Stroger Jr Hospital of Cook County, Chicago; Department of Endocrinology, Diabetes and Metabolism, Rush University Hospital, Chicago, IL, USA Abstract: We have now at our disposal the new rapid-acting insulin analogs, of which insulin lispro was the first to become commercially available. While the differences in pharmacokinetic and pharmacodynamic characteristics are indisputable, the clinical benefits attained by these changes have not been as clear. In the present review, we discuss the structure, pharmacology, and landmark studies related to insulin lispro. The clinical characteristics of insulin lispro are compared with those of insulin regular and other insulin analogs in different clinical situations. Also included are the aspects of quality of life and cost-effectiveness that may modify the modern practitioner's decision to adopt one type of insulin over another.