Clinical utility of folate-containing oral contraceptives

ical utility of folate-containing oral contraceptives Review (2440) Total Article Views Authors: Lassi ZS, Bhutta ZA Published Date April 2012 Volume 2012:4 Pages 185 - 190 DOI: http://dx.doi.org/10.2147/IJWH.S18611 Received: 12 January 2012 Accepted: 14 February 2012 Published: 23 April 2012 Zohra S Lassi, Zulfiqar A Bhutta Division of Women and Child Health, The Aga Khan University, Karachi, Pakistan Abstract: Folate is a generic term for a water-soluble B-complex vitamin which plays an important role in protein synthesis and metabolism and other processes related to cell multiplication and tissue growth. Pregnant and lactating women are at increased risk of folic acid deficiency because generally their dietary folate is insufficient to meet their physiological requirements and the metabolic demands of the growing fetus. The evidence pertaining to the reduction of the risk of neural tube defects (NTDs) due to folate is so compelling that supplementation with 400 μg of folic acid to all women trying to conceive until 12 weeks of pregnancy has been recommended by every relevant authority. A recent Cochrane review has also found protective effects of folate supplementation in occurrence and reoccurrence of NTDs. Despite food fortification and targeted public health campaigns promoting folic acid supplementation, 4,300,000 new cases occur each year worldwide resulting in an estimated 41,000 deaths and 2.3 million disability-adjusted life years (DALYS). This article will review the burden and risk factors of NTDS, and the role of folate in preventing NTDs. It will also describe different modes of supplementing folate and the newer evidence of the effectiveness of adding folate in oral contraceptives for raising serum and red blood cell folate levels.