OSA – a risk factor for stroke

– a risk factor for stroke Review (1549) Total Article Views Authors: Ryan CM Published Date December 2011 Volume 2011:1 Pages 43 - 57 DOI: http://dx.doi.org/10.2147/CPT.S16490 Clodagh M Ryan Centre for Sleep Health and Research, University of Toronto/Toronto General Hospital, Toronto, Canada Abstract: Obstructive sleep apnea is a sleep breathing disorder characterized by recurrent and intermittent hypoxia with continued respiratory effort against a closed glottis. The result of this is a cascade of acute and chronic systemic pathophysiological responses that cause endothelial dysfunction, atherosclerosis and lead to cardiovascular and cerebrovascular disease. This article focuses on the clinical evidence linking obstructive sleep apnea and stroke and on the specific mechanisms perpetuating stroke risk in this population.