Role of grape seed polyphenols in Alzheimer’s disease neuropathology

le of grape seed polyphenols in Alzheimer’s disease neuropathology Review (5094) Total Article Views Authors: Giulio Maria Pasinetti, Lap Ho Published Date August 2010 Volume 2010:2 Pages 97 - 103 DOI: http://dx.doi.org/10.2147/NDS.S6898 Giulio Maria Pasinetti1,2, Lap Ho1 1Department of Neurology, Mount Sinai School of Medicine, New York; 2Geriatric Research, Education and Clinical Center, James J Peters Veteran Affairs Medical Center, Bronx, New York, USA Abstract: Alzheimer’s disease (AD) is an age-related neurodegenerative condition -characterized by a progressive decline in cognitive function. AD affects approximately five million people in the US, creating a devastating financial burden on health care costs and an emotional -burden on caregivers. To date, there is no cure for AD, so researchers are continually exploring novel -avenues for the prevention and treatment of this condition. In this article, we present some -findings from our laboratory and those of others on the potential benefits of a grape seed -polyphenolic extract (GSPE) for the prevention and treatment of AD, including its c-hemical composition, bioactivity, bioavailability, safety, and tolerability, and the mechanisms by which it interferes with AD pathogenesis. Findings presented in this review article support the -development of GSPE as a preventative and/or therapeutic agent in AD.