Atypical glomus tumor of uncertain malignant potential in the urinary bladder

typical glomus tumor of uncertain malignant potential in the urinary bladder Case report (2745) Total Article Views Authors: Lindsay L Waters, Qihui "Jim" Zhai, J Scott Buie, et al Published Date December 2010 Volume 2010:2 Pages 141 - 144 DOI: http://dx.doi.org/10.2147/PLMI.S15791 Lindsay L Waters1, Qihui "Jim" Zhai4, J Scott Buie2, Rodney Miller2, John A Pumphrey3, Sang Wu2 1Department of Pathology, The Methodist Hospital, Houston, TX, USA; 2ProPath Associates, Dallas, TX, USA; 3Associates of Urology, Fort Worth, TX, USA; 4University of Cincinnati and Greater Cincinnati Pathologists Inc, Cincinnati, OH, USA Abstract: We present a case of an atypical glomus tumor of uncertain malignant potential in an 84-year-old woman with accompanied recurrent low-grade papillary urothelial carcinoma of the urinary bladder. Glomus tumor frequently occurs in the dermis or subcutis of extremities; its morphology includes round cells with pale-eosinophilic cytoplasm and central punched-out round to oval nucleus. Immunostains demonstrate muscle-specific- actin and desmin positivity and CD 34 negativity. Atypical glomus tumors of uncertain malignant potential are defined by lack of frank malignant features, in addition to high mitotic count, superficial location, or large size only, or deep location only. Our case is characterized by an abnormal proliferation of ovoid cells in the lamina propria, uniform ovoid nuclei with indistinct eosinophilic cytoplasm, sheet-like growth pattern with a prominent capillary network, mild nuclear atypia, and high mitotic rate. Immunostains showed tumor cells are positive for smooth muscle actin, smooth muscle myosin, and negative for CD 34. An English literature search revealed only one case of malignant glomus tumor but no atypical glomus tumors occurring in the urinary bladder. We described a case of atypical glomus tumor of uncertain malignant potential occurring in an unusual location, the urinary bladder.