Comparative Efficacy Of Topical Ciprofloxacin On Staphylococcus Aureus and Pseudomonas Aureginosa in vitro

Ciprofloxacinis often considered drug of first choice in the treatment of bacterial keratitis.Most of the ocular infections are caused by Staphylococcus aureus and Pseudomonas aeruginosa. This study set to compare the efficacy of ciprofloxacin on these two microorganisms in vitro. The “agar well diffusion” and the 10-fold serial dilution techniques were used respectively for the tests. Results of sensitivity test showed that P. aeruginosa aeruginosa had a higher meanzone of inhibition(4.72cm) than S. aureus (3.73cm), showingthat ciprofloxacin ismore efficacious against P. aeruginosathanagainst S. aureus. Ciprofloxacin is therefore recommended as drug of first choice in the treatment of ocular infections from Pseudomonas aeruginos.