Systemic lupus Erythematosus: 2 case reports from Eritrea

Systemic Lupus Erythematosus is an autoimmune disorder, occurring predominantly in women during reproductive age and characterized by the presence of antibodies in the serum against the nuclear components (ANA), leading to inflammation in kidney, brain, and skin manifestations. The diversity of the disease the clinical presentation with the accumulation of manifestations over time and the fluctuant disease course challenges many clinicians. Two cases of Systemic Lupus Erythematosus with different manifestations revealing, challenges in diagnostic, treatment, follow up and bleak prognosis are presented.