Metastatic Penile Carcinomas: A Study of Nine Cases and Review of the Literature

Objective: Primary penile carcinoma is one of the rarest male genital tract tumors in Turkey, because circumcision is performed routinely. In general, metastatic carcinoma of the penis is the second most common penile tumor. Despite the fact that the penis is rarely affected by metastases, there have been 319 cases reported in the literature. This study was carried out to throw light on the main characteristics of the metastatic disease. Patients and Methods: Nine patients aged between 32 and 68 years (median 62.9 years) with metastatic tumors of the penis were the subject of this study. The clinical history of the cases was reviewed, and the patients\' data were recorded including location, histology of the primary tumor, presence and location of other metastases, clinical findings, treatment and outcome. The microscopic preparations from both the primary tumor and the penile metastases were reviewed in our pathology department to confirm that the penile lesions showed the same histomorphological characteristics as the primary tumor. Results: The primary tumors were located in the genitourinary system in 7 / 9 patients(transitional cell carcinoma of the bladder), while in the remaining two patients the primary site was the lung (squamous cell carcinoma) and the bone marrow (lymphoblastic leukemia), respectively. Percutaneous needle aspiration cytology was performed in all cases and incisional biopsy in one case for diagnosis. Total penectomy was the treatment of choice in 7 cases and bilateral cavernotomy in the leukemia case. No treatment was given to one patient because of multiple metastases in other organs. Survival after treatment lasted from 4 months to 62 months; the longest survival (5 years) was found in the leukemia case. Conclusion: Metastatic penile carcinomas are relatively rare and present a challenging problem. Total penectomy and local excision of solitary nodules or distal penile involvement still represent the treatment of choice. However, because of the association of a penile metastatic lesion with advanced disease, survival rates are limited, and the majority of the patients die within one year. Carcinomes péniens métastatiques: Une étude de neuf cas et revue de la littérature Objectifs : Le carcinome pénien primitif est l\'une des tumeurs génitales masculines les plus rares en Turquie, parce que la circoncision est habituelle. En général, le carcinome métastatique du pénis est la deuxième tumeur pénienne commune. Malgré le fait que le pénis est rarement affecté par des métastases, il y a eu 319 cas rapportés dans la littérature. Cette étude a été réalisée pour déterminer les caractéristiques principales de la maladie métastatique. Patients et méthodes : Neuf patients de 32 à 68 ans (médiane 62,9 ans) présentant des tumeurs métastatiques du pénis étaient le sujet de cette étude. L\'histoire clinique de tous les patients a été revue, et les données des patients ont été enregistrées comprenant le siège, l\'histologie de la tum