Antimicrobial and cytotoxic activity of Streptomyces sp. from Lonar Lake

Antibacterial substances from actinomycetes were isolated from marine environment of Lonar Lake and characterized. Out of the 24 isolates subjected to secondary screening, 12 isolates were active against Bacillus subtilis, 13 against Staphylococcus aureus, 7 against Escherichia coli, 3 against Proteus vulgaris and 4 against Salmonella typhi. Metabolites in the extract of broth of 48 hrgrown Streptomyces spp. culture no.2 proved to have antimicrobial and cytotoxic against human lung carcinoma cell A549.