Evaluation of a Murine Model for Intranasal and Intraperitoneal Infection by Haemophilus parasuis: Short Report

NMRI mice were evaluated as model for experimental infection by Haemophilus parasuis by intranasal (IN) and intraperitoneal (IP) routes. No deaths, clinical signs and macroscopic lesions were noticed after receiving several doses (except when the mice were infected intraperitoneally with the highest dose), and the organism was cleared rapidly from spleen and lungs. These results suggest that NMRI mice are not a suitable model to reproduce experimentally Gl sser's disease.