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In vitro study of elution kinetics and bio-activity of meropenem-loaded acrylic bone cementDOI: 10.1007/s10195-012-0191-1 Keywords: Local antibiotic delivery,Extended-spectrum beta-lactamase producers,Gram-negative,Orthopaedic infections,Antibiotic bone cement Abstract: The elution of meropenem is in keeping with typical antibiotic-loaded acrylic bone cement elution characteristics. The use of high-dose meropenem-loaded acrylic bone cement seems to be an attractive option for treatment of resistant Gram-negative orthopaedic infections but needs to be tested in vivo.
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