| [1] | White RJ, Averner M (2001) Humans in space. Nature 409: 1115–1118.
|
| [2] | Committee on the Evaluation of Radiation Shielding for Space Exploration NRC (2008) Managing Space Radiation Risk in the New Era of Space Exploration. The National Academy Press.
|
| [3] | Cucinotta FA, Durante M (2006) Cancer risk from exposure to galactic cosmic rays: implications for space exploration by human beings. Lancet Oncol 7: 431–435.
|
| [4] | Ding LH, Shingyoji M, Chen F, Hwang JJ, Burma S, et al. (2005) Gene expression profiles of normal human fibroblasts after exposure to ionizing radiation: a comparative study of low and high doses. Radiat Res 164: 17–26.
|
| [5] | Sutherland BM, Bennett PV, Saparbaev M, Sutherland JC, Laval J (2001) Clustered DNA damages as dosemeters for ionising radiation exposure and biological responses. Radiat Prot Dosimetry 97: 33–38.
|
| [6] | Goodhead DT (1988) Spatial and temporal distribution of energy. Health Phys 55: 231–240.
|
| [7] | Spitz DR, Azzam EI, Li JJ, Gius D (2004) Metabolic oxidation/reduction reactions and cellular responses to ionizing radiation: a unifying concept in stress response biology. Cancer Metastasis Rev 23: 311–322.
|
| [8] | Georgakilas AG (2008) Processing of DNA damage clusters in human cells: current status of knowledge. Mol Biosyst 4: 30–35.
|
| [9] | Sutherland BM, Bennett PV, Schenk H, Sidorkina O, Laval J, et al. (2001) Clustered DNA damages induced by high and low LET radiation, including heavy ions. Phys Med 17: Suppl 1202–204.
|
| [10] | Chappell LJ, Whalen MK, Gurai S, Ponomarev A, Cucinotta FA, et al. (2010) Analysis of flow cytometry DNA damage response protein activation kinetics after exposure to x rays and high-energy iron nuclei. Radiat Res 174: 691–702.
|
| [11] | Shore RE (2009) Low-dose radiation epidemiology studies: status and issues. Health Phys 97: 481–486.
|
| [12] | Preston DL, Shimizu Y, Pierce DA, Suyama A, Mabuchi K (2003) Studies of mortality of atomic bomb survivors. Report 13: Solid cancer and noncancer disease mortality: 1950-1997. Radiat Res 160: 381–407.
|
| [13] | Hamada N, Maeda M, Otsuka K, Tomita M (2011) Signaling Pathways Underpinning the Manifestations of Ionizing Radiation-Induced Bystander Effects. Curr Mol Pharmacol 4: 79–95.
|
| [14] | Prise KM, O'Sullivan JM (2009) Radiation-induced bystander signalling in cancer therapy. Nat Rev Cancer 9: 351–360.
|
| [15] | Shao C, Furusawa Y, Kobayashi Y, Funayama T, Wada S (2003) Bystander effect induced by counted high-LET particles in confluent human fibroblasts: a mechanistic study. FASEB J 17: 1422–1427.
|
| [16] | Yang H, Anzenberg V, Held KD (2007) The time dependence of bystander responses induced by iron-ion radiation in normal human skin fibroblasts. Radiat Res 168: 292–298.
|
| [17] | Buonanno M, de Toledo SM, Pain D, Azzam EI (2011) Long-term consequences of radiation-induced bystander effects depend on radiation quality and dose and correlate with oxidative stress. Radiat Res 175: 405–415.
|
| [18] | Cerutti PA (1985) Prooxidant states and tumor promotion. Science 227: 375–381.
|
| [19] | Reznikoff CA, Brankow DW, Heidelberger C (1973) Establishment and characterization of a cloned line of C3H mouse embryo cells sensitive to postconfluence inhibition of division. Cancer Res 33: 3231–3238.
|
| [20] | Charlton DE, Sephton R (1991) A relationship between microdosimetric spectra and cell survival for high-LET irradiation. Int J Radiat Biol 59: 447–457.
|
| [21] | Azzam EI, de Toledo SM, Little JB (2003) Expression of CONNEXIN43 is highly sensitive to ionizing radiation and other environmental stresses. Cancer Res 63: 7128–7135.
|
| [22] | Balcer-Kubiczek EK, Harrison GH, Thompson BW (1987) Repair time for oncogenic transformation in C3H/10T1/2 cells subjected to protracted X-irradiation. Int J Radiat Biol Relat Stud Phys Chem Med 51: 219–226.
|
| [23] | Little JB (2003) Genomic instability and bystander effects: a historical perspective. Oncogene 22: 6978–6987.
|
| [24] | Azzam EI, de Toledo SM, Raaphorst GP, Mitchel RE (1996) Low-dose ionizing radiation decreases the frequency of neoplastic transformation to a level below the spontaneous rate in C3H 10T1/2 cells. Radiat Res 146: 369–373.
|
| [25] | Redpath JL, Antoniono RJ (1998) Induction of an adaptive response against spontaneous neoplastic transformation in vitro by low-dose gamma radiation. Radiat Res 149: 517–520.
|
| [26] | Elmore E, Lao XY, Kapadia R, Redpath JL (2009) Threshold-type dose response for induction of neoplastic transformation by 1 GeV/nucleon iron ions. Radiat Res 171: 764–770.
|
| [27] | Cucinotta FA, Nikjoo H, Goodhead DT (2000) Model for radial dependence of frequency distributions for energy imparted in nanometer volumes from HZE particles. Radiat Res 153: 459–468.
|
| [28] | NCRP (2006) Information needed to make radiation protection recommendations for space missions beyond low-earth orbit. Bethesda: National Council on Radiation Protection and Measurements. Report No. 153 Report No 153.
|
| [29] | Autsavapromporn N, de Toledo SM, Buonanno M, Jay-Gerin JP, Harris AL, et al. (2011) Intercellular Communication Amplifies Stressful Effects in High-Charge, High-Energy (HZE) Particle -Irradiated Human Cells. Journal of Radiation Research. In press.
|
| [30] | Autsavapromporn N, de Toledo SM, Little JB, Jay-Gerin JP, Harris AL, et al. (2011) The role of gap-junction communication and oxidative stress in the propagation of toxic effects among high dose alpha particle-irradiated human cells Radiat Res 175: 345–357.
|
| [31] | Gerashchenko BI, Howell RW (2005) Bystander cell proliferation is modulated by the number of adjacent cells that were exposed to ionizing radiation. Cytometry A 66: 62–70.
|
| [32] | Hei TK, Zhou H, Ivanov VN, Hong M, Lieberman HB, et al. (2008) Mechanism of radiation-induced bystander effects: a unifying model. J Pharm Pharmacol 60: 943–950.
|
| [33] | Azzam EI, de Toledo SM, Little JB (2001) Direct evidence for the participation of gap junction-mediated intercellular communication in the transmission of damage signals from alpha -particle irradiated to nonirradiated cells. Proc Natl Acad Sci U S A 98: 473–478.
|
| [34] | Trosko JE, Ruch RJ (2002) Gap junctions as targets for cancer chemoprevention and chemotherapy. Curr Drug Targets 3: 465–482.
|
| [35] | Raaphorst GP, Azzam EI (1986) Fixation and repair by anisotonic treatment of radiation damage leading to oncogenic transformation. Int J Radiat Biol Relat Stud Phys Chem Med 49: 383–393.
|
| [36] | Reznikoff CA, Bertram JS, Brankow DW, Heidelberger C (1973) Quantitative and qualitative studies of chemical transformation of cloned C3H mouse embryo cells sensitive to postconfluence inhibition of cell division. Cancer Res 33: 3239–3249.
|
| [37] | Brenner DJ, Miller RC, Huang Y, Hall EJ (1995) The biological effectiveness of radon-progeny alpha particles. III. Quality factors. Radiat Res 142: 61–69.
|
| [38] | Elmore E, Lao XY, Kapadia R, Redpath JL (2006) The effect of dose rate on radiation-induced neoplastic transformation in vitro by low doses of low-LET radiation. Radiat Res 166: 832–838.
|
| [39] | Rhim JS (1993) Neoplastic transformation of human cells in vitro. Crit Rev Oncog 4: 313–335.
|
| [40] | Sawant SG, Randers-Pehrson G, Geard CR, Brenner DJ, Hall EJ (2001) The bystander effect in radiation oncogenesis: I. Transformation in C3H 10T1/2 cells in vitro can be initiated in the unirradiated neighbors of irradiated cells. Radiat Res 155: 397–401.
|
| [41] | Miller RC, Randers-Pehrson G, Geard CR, Hall EJ, Brenner DJ (1999) The oncogenic transforming potential of the passage of single alpha particles through mammalian cell nuclei. Proc Natl Acad Sci U S A 96: 19–22.
|
| [42] | Durante M, Loeffler JS (2009) Charged particles in radiation oncology. Nat Rev Clin Oncol 7: 37–43.
|
| [43] | Okada T, Kamada T, Tsuji H, Mizoe JE, Baba M, et al. (2010) Carbon ion radiotherapy: clinical experiences at National Institute of Radiological Science (NIRS). J Radiat Res (Tokyo) 51: 355–364.
|
| [44] | Azzam EI, Raaphorst GP, Mitchel RE (1994) Radiation-induced adaptive response for protection against micronucleus formation and neoplastic transformation in C3H 10T1/2 mouse embryo cells. Radiat Res 138: S28–31.
|
| [45] | Terasima T, Tolmach LJ (1963) X-ray sensitivity and DNA synthesis in synchronous populations of HeLa cells. Science 140: 490–492.
|
| [46] | Schillaci ME, Carpenter S, Raju MR, Sebring RJ, Wilder ME, et al. (1989) Radiobiology of ultrasoft X rays. II. Cultured C3H mouse cells (10T1/2). Radiat Res 118: 83–92.
|
| [47] | Rueckert RR, Mueller GC (1960) Effect of oxygen tension on HeLa cell growth. Cancer Res 20: 944–949.
|
| [48] | Gray LH, Conger AD, Ebert M, Hornsey S, Scott OC (1953) The concentration of oxygen dissolved in tissues at the time of irradiation as a factor in radiotherapy. Br J Radiol 26: 638–648.
|
| [49] | Puck TT, Marcus PI (1956) Action of x-rays on mammalian cells. J Exp Med 103: 653–666.
|
