全部 标题 作者
关键词 摘要

OALib Journal期刊
ISSN: 2333-9721
费用:99美元

查看量下载量

相关文章

更多...
PLOS ONE  2011 

Differential Development of Human Brain White Matter Tracts

DOI: 10.1371/journal.pone.0023437

Full-Text   Cite this paper   Add to My Lib

Abstract:

Neuroscience is increasingly focusing on developmental factors related to human structural and functional connectivity. Unfortunately, to date, diffusion-based imaging approaches have only contributed modestly to these broad objectives, despite the promise of diffusion-based tractography. Here, we report a novel data-driven approach to detect similarities and differences among white matter tracts with respect to their developmental trajectories, using 64-direction diffusion tensor imaging. Specifically, using a cross-sectional sample comprising 144 healthy individuals (7 to 48 years old), we applied k-means cluster analysis to separate white matter voxels based on their age-related trajectories of fractional anisotropy. Optimal solutions included 5-, 9- and 14-clusters. Our results recapitulate well-established tracts (e.g., internal and external capsule, optic radiations, corpus callosum, cingulum bundle, cerebral peduncles) and subdivisions within tracts (e.g., corpus callosum, internal capsule). For all but one tract identified, age-related trajectories were curvilinear (i.e., inverted ‘U-shape’), with age-related increases during childhood and adolescence followed by decreases in middle adulthood. Identification of peaks in the trajectories suggests that age-related losses in fractional anisotropy occur as early as 23 years of age, with mean onset at 30 years of age. Our findings demonstrate that data-driven analytic techniques may be fruitfully applied to extant diffusion tensor imaging datasets in normative and neuropsychiatric samples.

References

[1]  Giedd J, Rapoport J (2010) Structural MRI of pediatric brain development: what have we learned and where are we going? Neuron 67: 728–734.
[2]  Huttenlocher P (1979) Synaptic density in human frontal cortex - developmental changes and effects of aging. . Brain Res 163: 195–205.
[3]  Rakic P, Goldmanrakic PS, Gallager D (1988) Quantitative Autoradiography of Major Neurotransmitter Receptors in the Monkey Striate and Extrastriate Cortex. Journal of Neuroscience 8: 3670–3690.
[4]  Rakic P, Bourgeois JP, Eckenhoff MF, Zecevic N, Goldmanrakic PS (1986) Concurrent Overproduction of Synapses in Diverse Regions of the Primate Cerebral-Cortex. Science 232: 232–235.
[5]  Casey BJ, Giedd JN, Thomas KM (2000) Structural and functional brain development and its relation to cognitive development. Biological Psychology 54: 241–257.
[6]  Shaw P, Kabani NJ, Lerch JP, Eckstrand K, Lenroot R, et al. (2008) Neurodevelopmental trajectories of the human cerebral cortex. Journal of Neuroscience 28: 3586–3594.
[7]  LeBihan D (1995) Molecular diffusion, tissue microdynamics and microstructure. Nmr in Biomedicine 8: 375–386.
[8]  Klingberg T, Vaidya CJ, Gabrieli JD, Moseley ME, Hedehus M (1999) Myelination and organization of the frontal white matter in children: a diffusion tensor MRI study. Neuroreport 10: 2817–2821.
[9]  Pfefferbaum A, Mathalon DH, Sullivan EV, Rawles JM, Zipursky RB, et al. (1994) A Quantitative Magnetic-Resonance-Imaging Study of Changes in Brain Morphology from Infancy to Late Adulthood. Archives of Neurology 51: 874–887.
[10]  Salat DH, Tuch DS, Greve DN, van der Kouwe AJW, Hevelone ND, et al. (2005) Age-related alterations in white matter microstructure measured by diffusion tensor imaging. Neurobiology of Aging 26: 1215–1227.
[11]  Ashtari M, Cervellione KL, Hasan KM, Wu J, McIlree C, et al. (2007) White matter development during late adolescence in healthy males: A cross-sectional diffusion tensor imaging study. Neuroimage 35: 501–510.
[12]  Giorgio A, Watkins KE, Douaud G, James AC, James S, et al. (2008) Changes in white matter microstructure during adolescence. Neuroimage 39: 52–61.
[13]  Qiu DQ, Tan LH, Zhou K, Khong PL (2008) Diffusion tensor imaging of normal white matter maturation from late childhood to young adulthood: Voxel-wise evaluation of mean diffusivity, fractional anisotropy, radial and axial diffusivities, and correlation with reading development. Neuroimage 41: 223–232.
[14]  Schmithorst VJ, Wilke M, Dardzinski BJ, Holland SK (2002) Correlation of white matter diffusivity and anisotropy with age during childhood and adolescence: A cross-sectional diffusion-tensor MR imaging study. Radiology 222: 212–218.
[15]  Barnea-Goraly N, Menon V, Eckert M, Tamm L, Bammer R, et al. (2005) White Matter Development During Childhood and Adolescence: A Cross-sectional Diffusion Tensor Imaging Study. Cerebral Cortex 15: 1848–1854.
[16]  Giorgio A, Watkins KE, Chadwick M, James S, Winmill L, et al. (2010) Longitudinal changes in grey and white matter during adolescence. Neuroimage 49: 94–103.
[17]  Westlye LT, Walhovd KB, Dale AM, Bjornerud A, Due-Tonnessen P, et al. (2009) Life-Span Changes of the Human Brain White Matter: Diffusion Tensor Imaging (DTI) and Volumetry. Cereb Cortex: bhp280.
[18]  Lebel C, Walker L, Leemans A, Phillips L, Beaulieu C (2008) Microstructural maturation of the human brain from childhood to adulthood. Neuroimage 40: 1044–1055.
[19]  Michielse S, Coupland N, Camicioli R, Carter R, Seres P, et al. (2010) Selective effects of aging on brain white matter microstructure: A diffusion tensor imaging tractography study. Neuroimage 52: 1190–1201.
[20]  Tamnes CK, Ostby Y, Fjell AM, Westlye LT, Due-Tonnessen P, et al. (2010) Brain Maturation in Adolescence and Young Adulthood: Regional Age-Related Changes in Cortical Thickness and White Matter Volume and Microstructure. Cerebral Cortex 20: 534–548.
[21]  Behrens TEJ, Berg HJ, Jbabdi S, Rushworth MFS, Woolrich MW (2007) Probabilistic diffusion tractography with multiple fibre orientations: What can we gain? Neuroimage 34: 144–155.
[22]  MacQueen JB (1967) Some Methods for classification and Analysis of Multivariate Observations. Proceedings of 5-th Berkeley Symposium on Mathematical Statistics and Probability 1: 281–297.
[23]  Smith SM, Johansen-Berg H, Jenkinson M, Rueckert D, Nichols TE, et al. (2007) Acquisition and voxelwise analysis of multi-subject diffusion data with Tract-Based Spatial Statistics. Nature Protocols 2: 499–503.
[24]  Colibazzi T, Zhu H, Bansal R, Schultz RT, Wang Z, et al. (2008) Latent volumetric structure of the human brain: Exploratory factor analysis and structural equation modeling of gray matter volumes in healthy children and adults. Hum Brain Mapp 29: 1302–1312.
[25]  Zielinski BA, Gennatas ED, Zhou J, Seeley WW (2010) Network-level structural covariance in the developing brain. Proc Natl Acad Sci U S A 107: 18191–18196.
[26]  Davies DL, Bouldin DW (1979) Cluster Separation Measure. Ieee Transactions on Pattern Analysis and Machine Intelligence 1: 224–227.
[27]  Kaufman J, Birmaher B, Brent D, Rao U, Flynn C, et al. (1997) Schedule for Affective Disorders and Schizophrenia for School-Age Children Present and Lifetime version (K-SADS-PL): Initial reliability and validity data. Journal of the American Academy of Child and Adolescent Psychiatry 36: 980–988.
[28]  First MB (2002) The DSM series and experience with DSM-IV. Psychopathology 35: 67–71.
[29]  Adler L, Spencer T (2004) The Adult ADHD Clinical Diagnostic Scale (ACDS) V 1.2. New York, , NY: New York University School of Medicine.
[30]  Jones DK, Horsfield MA, Simmons A (1999) Optimal strategies for measuring diffusion in anisotropic systems by magnetic resonance imaging. Magnetic Resonance in Medicine 42: 515–525.
[31]  Jenkinson M (2003) Fast, automated, N-dimensional phase-unwrapping algorithm. Magnetic Resonance in Medicine 49: 193–197.
[32]  Rueckert D, Sonoda LI, Hayes C, Hill DLG, Leach MO, et al. (1999) Non-rigid registration using free-form deformations: Application to breast MR images. IEEE Transactions on Medical Imaging 18: 712–721.
[33]  Andersson JLR, Jenkinson M, Smith. S (2007) Non-linear registration, aka Spatial normalisation FMRIB.
[34]  Zuo X, Kelly C, Di Martino A, Mennes M, Margulies D, et al. (2010) Growing together and growing apart: regional and sex differences in the lifespan developmental trajectories of functional homotopy. J Neurosci 30: 15034–15043.
[35]  Ward JH (1963) Hierarchical Grouping to Optimize an Objective Function. Journal of the American Statistical Association 58: 236–244.
[36]  Smith S, Nichols T (2009) Threshold-free cluster enhancement: addressing problems of smoothing, threshold dependence and localisation in cluster inference. Neuroimage 44: 83–98.
[37]  Mori S, Oishi K, Jiang H, Jiang L, Li X, et al. (2008) Stereotaxic white matter atlas based on diffusion tensor imaging in an ICBM template. Neuroimage 40: 570–582.
[38]  Hoptman M, Davidson R (1994) How and why do the two cerebral hemispheres interact? Psychol Bull 116: 195–219.
[39]  LaMantia A, Rakic P (1990) Axon overproduction and elimination in the corpus callosum of the developing rhesus monkey. J Neurosci 10: 2156–2175.
[40]  Yakovlev PI (1954) Anatomical studies in frontal leucotomies. II. Cortical origin of the fronto-pontine tract and organization of the thalamo-frontal projections. Trans Am Neurol Assoc 13: 53–56.
[41]  Stieltjes B, Kaufmann WE, van Zijl PC, Fredericksen K, Pearlson GD, et al. (2001) Diffusion tensor imaging and axonal tracking in the human brainstem. Neuroimage 14: 723–735.
[42]  Hewitt W (1961) The development of the human internal capsule and lentiform nucleus. J Anat 95: 191–199.
[43]  Jellison BJ, Field AS, Medow J, Lazar M, Salamat MS, et al. (2004) Diffusion tensor imaging of cerebral white matter: a pictorial review of physics, fiber tract anatomy, and tumor imaging patterns. AJNR Am J Neuroradiol 25: 356–369.
[44]  Ross ED (1980) Localization of the pyramidal tract in the internal capsule by whole brain dissection. Neurology 30: 59–64.
[45]  ffytche DH, Catani M (2005) Beyond localization: from hodology to function. Philos Trans R Soc Lond B Biol Sci 360: 767–779.
[46]  Thomsen C, Henriksen O, Ring P (1987) In vivo measurement of water self diffusion in the human brain by magnetic resonance imaging. Acta Radiol 28: 353–361.
[47]  Pierpaoli C, Jezzard P, Basser PJ, Barnett A, Di Chiro G (1996) Diffusion tensor MR imaging of the human brain. Radiology 201: 637–648.
[48]  Guevara P, Poupon C, Riviere D, Cointepas Y, Descoteaux M, et al. (2010) Robust clustering of massive tractography datasets. Neuroimage.
[49]  Peng H, Orlichenko A, Dawe RJ, Agam G, Zhang S, et al. (2009) Development of a human brain diffusion tensor template. Neuroimage 46: 967–980.
[50]  Peng H, Arfanakis K (2007) Diffusion tensor encoding schemes optimized for white matter fibers with selected orientations. Magn Reson Imaging 25: 147–153.
[51]  Assaf Y, Pasternak O (2008) Diffusion tensor imaging (DTI)-based white matter mapping in brain research: a review. J Mol Neurosci 34: 51–61.
[52]  Tuch DS (2004) Q-ball imaging. Magn Reson Med 52: 1358–1372.
[53]  Ge YL, Grossman RI, Babb JS, Rabin ML, Mannon LJ, et al. (2002) Age-related total gray matter and white matter changes in normal adult brain. Part I: Volumetric MR imaging analysis. American Journal of Neuroradiology 23: 1327–1333.
[54]  Salat DH, Tuch DS, Hevelone ND, Fischl B, Corkin S, et al. (2005) Age-related changes in prefrontal white matter measured by diffusion tensor imaging. Ann N Y Acad Sci 1064: 37–49.
[55]  Raz N, Gunning FM, Head D, Dupuis JH, McQuain J, et al. (1997) Selective aging of the human cerebral cortex observed in vivo: differential vulnerability of the prefrontal gray matter. Cereb Cortex 7: 268–282.
[56]  Raz N, Williamson A, Gunning-Dixon F, Head D, Acker JD (2000) Neuroanatomical and cognitive correlates of adult age differences in acquisition of a perceptual-motor skill. Microsc Res Tech 51: 85–93.
[57]  Damoiseaux JS, Greicius MD (2009) Greater than the sum of its parts: a review of studies combining structural connectivity and resting-state functional connectivity. Brain Struct Funct 213: 525–533.
[58]  Kelly C, Uddin LQ, Shehzad Z, Margulies DS, Castellanos FX, et al. (2010) Broca's region: linking human brain functional connectivity data and non-human primate tracing anatomy studies. Eur J Neurosci 32: 383–398.
[59]  Bellec P, Rosa-Neto P, Lyttelton OC, Benali H, Evans AC (2010) Multi-level bootstrap analysis of stable clusters in resting-state fMRI. Neuroimage 51: 1126–1139.
[60]  Cohen AL, Fair DA, Dosenbach NU, Miezin FM, Dierker D, et al. (2008) Defining functional areas in individual human brains using resting functional connectivity MRI. Neuroimage 41: 45–57.
[61]  Beckmann M, Johansen-Berg H, Rushworth MF (2009) Connectivity-based parcellation of human cingulate cortex and its relation to functional specialization. J Neurosci 29: 1175–1190.
[62]  Margulies DS, Bottger J, Long X, Lv Y, Kelly C, et al. (2010) Resting developments: a review of fMRI post-processing methodologies for spontaneous brain activity. MAGMA 23: 289–307.
[63]  Bullmore E, Sporns O (2009) Complex brain networks: graph theoretical analysis of structural and functional systems. Nat Rev Neurosci 10: 186–198.
[64]  Sporns O, Zwi JD (2004) The small world of the cerebral cortex. Neuroinformatics 2: 145–162.
[65]  Sporns O, Tononi G, Edelman GM (2000) Theoretical neuroanatomy: relating anatomical and functional connectivity in graphs and cortical connection matrices. Cereb Cortex 10: 127–141.
[66]  Craddock RC, Holtzheimer PE 3rd, Hu XP, Mayberg HS (2009) Disease state prediction from resting state functional connectivity. Magn Reson Med 62: 1619–1628.
[67]  Dosenbach NU, Nardos B, Cohen AL, Fair DA, Power JD, et al. (2010) Prediction of individual brain maturity using fMRI. Science 329: 1358–1361.
[68]  Raj A, Hess C, Mukherjee P (2011) Spatial HARDI: improved visualization of complex white matter architecture with Bayesian spatial regularization. Neuroimage 54: 396–409.
[69]  Sosnovik DE, Wang R, Dai G, Wang T, Aikawa E, et al. (2009) Diffusion spectrum MRI tractography reveals the presence of a complex network of residual myofibers in infarcted myocardium. Circ Cardiovasc Imaging 2: 206–212.
[70]  Wedeen VJ, Wang RP, Schmahmann JD, Benner T, Tseng WY, et al. (2008) Diffusion spectrum magnetic resonance imaging (DSI) tractography of crossing fibers. Neuroimage 41: 1267–1277.

Full-Text

Contact Us

service@oalib.com

QQ:3279437679

WhatsApp +8615387084133