EVALUACIóN DE LOS EFECTOS CARDIOVASCULARES DEL EXTRACTO Y COMPUESTOS DE Solanum tuberosum EN RATA DESMEDULADA

this study evaluates the effects on arterial pressure and pithed heart frequency rate induced by the ethanolic extract of solanum tuberosum, a species used in colombian folk medicine for the treatment or arterial hypertension, compared with α-solanine and α-chaconine -the main glycoalcaloids of s. tuberosum- the mixture of both glycoalcaloids (50:50) and chlorogenic acid, the main polyphenolic compound present in this species. the effect of the extract in presence of noradrenalin (0.25 - 2.5 μg/kg, iv) and l-name (10 mg/kg, iv), inhibitor of nitric oxide sintase, is also studied. these results show that whereas the etanolic extract decreases the blood pressure in a dose - response manner (1 μg/kg - 10 mg/kg, iv) and reduces the increase of this variable induced by noradrenalin. it has been not demonstrated that the glycoalcaloid compounds, the alkaloidal mixture (50:50), or the chlorogenic acid were able to reduce the arterial pressure. the effect of the extract is reverted partially in the presence of l-name. in conclusion, the etanolic extract of s. tuberosum exerts hypotensive effects related partially with the nitric oxide production, non-attributable to the presence of α-solanine, α-chaconine or chlorogenic acid.