Determinación de residuos de oxitetraciclina en muestras De tejido bovino destinadas al consumo humano

oxytetracyclines (otc) are wide spectrum antimicrobials that have been used indiscriminately in veterinary medicine. these drugs can remain as chemical residues in foodstuff, which could lead to serious health problems, such as development of bacterial resistance, allergies, ossification and dentition disturbances, and carcinogenic effects. in venezuela, there are no government regulations regarding dosage regimens, frequency of application and withdrawal times for otcs. neither there are official inspection agencies that scrutinize the presence of residues and establish the suggested maximum limits of residues (mlsrs) for food products of animal origin. this research evaluated the presence of otc residues in organ samples of bovine used for human consumption, from beneficiadora industrial maracay. samples of muscle, liver and kidney were used. in order to compare de values obtained in this investigation, we used the mlrs values established by the world health organization (who), such values correspond to 250ng/g. results of this investigation, show that otc were detected in 89.3% of all tissuesamples evaluated, with a mean otc residue of 781,54 ng/g ±1033,29. these values are higher than the already established mlsrs. the mean otc value for each tissue sample was: 533,84 ng/g ±527,92 for muscle; 917,16 ng/g ± 1295,41 for liver and; 819,14 ng/g ±859,18 for kidney respectively. these results suggest that there is not an adequate monitoring for withdrawal times in terms of otc in veterinary practice.