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Pronóstico materno y perinatal en el embarazo con deficiencia del factor XII

DOI: 10.4067/S0717-75262012000100004

Keywords: pregnancy, factor xii deficiency, thrombosis, recurrent abortion, heparin.

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Abstract:

background: the factor xii deficiency is a rare disease related with thrombosis and recurrent pregnancy loss. objective: to evaluate maternal and perinatal outcome in 25 pregnant women with deficiency of factor xii. methods: an observational descriptive study of 25 women with factor xii deficiency and pregnancy (27 pregnancies) between january 2005 and march 2011. results: the association with other inherited or acquired thrombophilia is common. 24 women have achieved successful pregnancies and only 3 miscarriages. there were 20 women with deliveries at term, with appropiate birth weight and apgar test. there was one case of intrauterine growth restriction. there were no medical complications. the treatment used was antiplatelet and/or antithrombotic agents in all cases. the most used drug was low molecular weight heparin, sometimes associated to acetylsalicylic acid. conclusions: a multidisciplinary control of the pregnancy and an individualized treatment has achieved good maternal and neonatal outcomes.

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