Diferencias en la aterosclerosis coronaria entre hombres y mujeres con Diabetes Mellitus tipo 2 evaluados con el Score de Gensini

diabetic women have higher morbidity and mortality associated with ischemic coronary events than diabetic men, but the extension of coronary artery disease in both groups is less well established. aim: to compare the extension, magnitude and severity of coronary atherosclerosis between men and women with type 2 diabetes mellitus. method: 162 consecutive diabetic patients with suspected coronary atherosclerosis studied by coronary angiography were included. the magnitude of atherosclerosis was quantified using the gensini score. results: the average age was 64.8 years. ninety-four patients were women (58.0%). diabetes was present for 152 ± 90.0 months for women and 120 ± 99.4 months for men (p <0.05). women had a higher body mass index (30.5 ± 5.1) than men (28.5 ± 5.2, p<0.05). the presence of significant coronary atherosclerosis in the entire diabetic population was of 61.7%: 76.5% in men and 51.5% in women (or 1.5). the mean number of atherosclerotic plaques was 195 in 68 men (2.86 plaques/patient) and 168 in 94 women (1.78 plaques/patient, p=0.0043). significant atherosclerosis in 1, 2 and 3 vessels was observed in 7.4%, 17.6% and 51.5% of men, respectively, versus 12.8%, 10.6% and 27.7% in women (p<0.0002). the magnitude of coronary disease measured by gensini score was 69.4 + 66.7 in men versus 35.6 ± 47.3 in women (p<0.005). conclusion: men with diabetes have greater extension, magnitude and severity of coronary atherosclerosis than diabetic women.