Falla ovárica prematura

premature ovarian failure (pof), also called precocious menopause, is the cessation of the ovarian function prior to the age of 40. this pathology affects 1-2 % women below 40 years of age. there are many factors inducing pof, however most frequent are of immunological, pharmacological and genetic origin. chemotherapy is the most common pharmacological cause. there are many candidate genes for inducing pof, which it makes necessary to find in every population mutations or polymorphisms that best correlate with the phenotype. treatment of pof must be directed not only to prevent long term pathologies but also to achieve a good quality of life.