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Aspectos fisiopatológicos y moleculares en la remodelación de la matriz extracelular vascular

Keywords: extracelar matrix, remodeling, arteries.

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Abstract:

in arterial remodeling, as well as in various body tissues, the extracellular matrix plays an important role. remodeling is a phenomenon which is difficult to reproduce experimentally because the makeup of the matrix is complex. in the case of arteries, a key factor is the change in the smooth muscle-matrix relation, which causes the phenotype of the smooth muscle to change from contractile to secretory. for the changes to occur in the matrix and smooth muscle, the activation of protease-encoding genes is essential, since they modify the cell-cell and cell-matrix relations.

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