Radioterapia estereotáctica extracraneal un nuevo paradigma en terapéutica oncológica experiencia preliminar

objectives: present the preliminary results obtained with stereotactic body radiation therapy in liver metastases, pulmonary tumors and other metastatic lesions. methods: treatment is described, presenting a prospective analysis of 25 patients treated in la trinidad radiation therapy service since march 2009. patients were treated using a dual energy ix varian？ linear accelerator trilogy version, with on board imaging. doses of radiation varied from 60 gy in 3 fractions to 44.5 gy in 10 fractions. follow up time varied from < 1 month to 16 months. results: total of 25 patients were included in the study (44 lesions); 14 patients with liver metastases, 5 with lung metastases (3 of them also received treatment for liver metastases), 4 primary lung tumors, 2 vertebral metastases, and 3 with other metastatic lesions. treatment was in general well tolerated with no serious complications. partial regression or stabilization of the treated lesions occurred in 17 patients, persistence or local progression was seen in 3 patients. in13 individuals there was no appearance of new metastatic disease and10 showed progression of distant disease, during this limited follow up time. four patients have died with disease. conclusions: stereotactic body radiation is a novel high precision radiation therapy technique with a great potential in the multidisciplinary management of patients with neoplastic disease. the preliminary results of this study and the review of the literature support the safety, and effectiveness of this treatment modality and the feasibility of employing in venezuela