Marcadores inflamatorios en diabetes mellitus Tipo 1: Relación con perfil lipídico, control metabólico y duración de la enfermedad

objective: to determine the levels of inflammatory markers in patients with dm1 compared to controls without dm1, and their relationship with lipid profile, metabolic control and duration of diabetes. materials and methods: we selected 38 patients from the endocrinology service of iahula, mérida (n = 13) and táchira endocrinologist consultations (n = 25) with dm1 without chronic complications of diabetes (study group). we selected 40 patients without diabetes mellitus, adjusted for age and sex to patients, who formed the control group. we used a questionnaire covering demographic data and physical examination. then we calculated the body mass index and laboratory tests in serum were performed: glucose, triglycerides, total cholesterol, ldl-c, hdl-c, hba1c, c-reactive protein (crp) and tumour necrosis factor (tnfα). results: there was no statistical difference between study and control groups regarding age, weight, height and body mass index (bmi). systolic blood pressure (sbp) was higher in the study group (dm1; p=0.017). hdlc levels were significantly higher in the group of diabetic children (p=0.0001) and there were no significant differences in the other lipid. levels crp was not different between groups but showed a significant positive correlation with markers of adiposity (bmi and waist circumference) (p=0.0001), arterial blood pressure (p=0.002) and duration of diabetes (p=0.02). the fntα was significantly higher in type 1 diabetic patients and showed a strong positive correlation with hyperglycemia (p=0.0001) and weak with sbp (p=0.01). conclusions: ftnα increased levels in diabetic children and the positive correlations of this factor with glycemia, as well as pcr with adiposity, blood pressure and duration of dm1, suggest a possible relationship between inflammatory markers and dm1, however, follow-up studies are needed to determine its importance.