Hiperfosfatasemia transitoria de la infancia: A propósito de dos casos

objective: to report two cases of benign transient hyperphosphatasemia of infancy (bthi). methods: clinical, laboratory finding and bone mineral density (bmd) results are presented and the literature about bhti is reviewed.clinical cases: we studied two cases of bhti. case 1. girl of 7.6 years old with a history of rheumatoid arthritis and weight deficit. the last 4 months she has suffered upper respiratory tract infection, without other clinical, biochemical, or densitometric alteration except for high alkaline phosphatase (alp) values (1650 u/l). alp values were normalized spontaneously one year later. case 2. male child of 10.1 years old, overweight, without personal pathologies, with high levels of alp (1200u/l) wich showed a favorable and spontaneous normalization at 8 months (260 u/l).conclusions: the bhti is a benign self-limited disease that resolves spontaneously, without clinical or labora-tory evidence of bone, liver or endocrine disorder. it courses with elevation of alp, 3-20 times above normal values for age, and most of the time are normalized within 4 months. the exact etiology is unknown, but their finding in the context of respiratory and gastrointestinal viruses, indicates a probable infectious etiology. the bthi should be considered in the diagnostic evaluation of hyperphosphatasemia in order to avoid unneces-sary tests.