EL BOSTEZO INDUCIDO POR APOMORFINA EN RATAS ALCOHOLIZADAS EN PERIODO DE ABSTINENCIA: EVIDENCIAS DE UN MECANISMO DOPAMINERGICO POSTSINAPTICO

there are two theories to explain the apomorphine induced yawning: the pre synaptic one and the post synaptic one. alcoholic abstinence may provide evidence of the second one considering the dopaminergic hypersensitivity that it causes. wister alcoholic rats were deprived of alcohol and the apomorphine test was performed during abstinence. the same procedure was performed on non alcoholic rats. media rate of the apomorphine group was higher than in the rest. those treated with apomorphine and treated with placebo showed similar records. we consider that apomorphine acts with hypersensitive postsynaptic receptors due to alcoholic abstinence and not because of auto receptors inhibiting dopamine liberation, given that hypersensitivity is increased in abstinent groups because of the inhibition of dopamine liberation, and according to the first theory, the group treated with placebo, should have showed a larger number of yawning than the rest.