Efecto de Uncaria tomentosa en la mutagénesis de Salmonella typhimurium inducida por 7,12 dimetilbenzantranceno con activación metabólica in vitro

objective: to verify the anitmutagenic properties of uncaria tomentosa (willd. ex roem. & schult.) dc. in a model of modified ames' test. methods: a prospective experimental study was conducted by using an auxotrophic strain of salmonella typhimurium ta-102 his(-) in 2 groups, one control and one experimental; the latter was divided into 4 subgroups treated with increasing doses of u. tomentosa. mutagenesis was induced in both groups with 7,12 dimethylbenzanthracene in a system of metabolic activation with freeze-dried of liver microsomes. to establish the statistical significance, the student's t test was used. results: it was observed a reversal of colonies inversely proportional to the dose of freeze-dried of u. tomentosa; the average count was 333 ± 14 colonies/plaque for the dose of 750 mg, whereas for the control group it was 606 ± 21 colonies/plaque with a statistically significant difference (p< 0,05). conclusions: u. tomentosa has antimutagenic properties in this experimental model.