Empleo de la diafiltración en el lavado de cultivos de Leptospira interrogans canicola canicola para la producción de la vacuna vax-SPIRAL

it was proposed to substitute the present technology of the lavage operation for a tangential microfiltration system at the lavage stages of the culture of leptospira interrogans canicola canicola. it was proved that this system may be applied, since no cellular affectation was observed and high pollutant elimination levels were obtained.