Anemia drepanocítica y enfermedad de Castleman

castleman's disease is a rare lymphoproliferative process characterized by benign hyperplasia of the lymph nodes. there are 2 distinct histologic variants: hyaline-vascular and cellular plasmodia, which in turn, may be localized or multicentric. the hyaline vascular form is usually asymptomatic and most often located in the mediastinum, whereas cellular plasmodia frequently presents with systemic symptoms and it is usually diffuse or multicentric. due to the rarity of this association, we present a case with a history of sickle cell disease 12 years after diagnosis of localized castleman's disease, plasma cell variant and total excision, lymph node had a relapse with the same variant, having good clinical treatment response.