Análisis de las dosificaciones en los esquemas de citostáticos en el cáncer de mama

a retrospective study was conducted between january and june, 2003 to review the medical indications and the medical histories of 183 patients with breast cancer that received attention at the institute of oncology and radiobiology, and that were administered intravenous mixtures of antineoplastic agents as part of their treatment. variables such as age, weight, height, pathological history, schemes of prescribed antineoplastic agents and posology were taken into account to make this analysis. this allowed to establish an adequate selection of the treatments and to define the right dosage for each patient. patients aged 40-59 predominated in the studied sample. 67 patients presented pathological history and the highest frequency was observed at ages over 50. the most used mixtures of antineoplastic agents corresponded to cyclophosphamide-metotrexate-5-fluorouracil (cmf), and cyclophosphamide-doxorubicin-5-fluoracil (cdf). 61 medication errors were detected, accounting for 33.3 % of the total of the sample. 20 of them (11 %) due to overdosage and 1 patient that had the use of doxorubicin contraindicated because of his pathological history. it was proved that the incorporation of the professional pharmacist to the multidisciplinary team of oncological drug therapy was necessary to provide an assistance with a better quality and to prevent potential or real risks produced by the inadequate use of antineoplastic agents.