Desarrollo y validación de una metodología para la limpieza de áreas de producción de tabletas de penicilamina

a cleaning methodology was developed to be used in production and development areas, where work with penicillamine is done. it is a highly contaminating and toxic compound. a method was validated by high performance liquid chromatography that was selected due to the versatility of this type of techniques for detecting traces. the method proved to be specific, lineal, accurate and precise in the range of working concentrations. the limits of detection and quantification were determined. the sampling method by brushing was used and satisfactory results were attained. it was concluded that the cleaning procedures were effective for the worst of the settings