Efectos del extracto de alcoholes purificados de la cera de abejas (Apis mellifera) en dos modelos de analgesia

the d-002 is a mixture of 6 high molecular weight aliphatic acids purified from bee wax (apis mellifera). the aim of present study was to research the effects of an oral treatment using d-002 on the acetic acid- induced abdominal writhings and in the hot plate model in mice. animals were randomized distributed to 5 groups (10-20 animals/group): a control one received the gum arabic vehicle/h20, three received d-002 (25, 125 and 250 mg/kg), and another received aspirin (abdominal contortions model) or morphine (hot plate). the d-002 inhibited the above mentioned writhings in a 44., 44,8 and 47. , respectively; however, not modified the response latency in the hot plate model. these results demonstrate that the d-002 (25-250 mg/kg) oral treatment may to inhibit in a moderate way the above mentioned writhings without to affect the response to hot plate. it suggests that the d-002 exerts a peripheral analgesic action but not a central level.