Ion-exchange resin complexation: Masking the bitter taste of cefuroxime axetil

objective: the purpose of this research was to formulate taste masked complexes of cefuroxime axetil and to evaluate them for taste, drug loading and characterized by ftir, xrd. tablets were formulated of selected batches and evaluated for drug release and physical parameters. methods: complexation technique is used to prepare complexes of drug where ion exchange resins such as indion？ 214, indion？ 234 and indion？ 414 were used with a drug-resin ratio of 1:0.5, 1:1, 1:2. the drug resinates were characterized by infrared spectroscopy, dsc and x-ray diffraction pattern and evaluated for drug loading and taste. direct compression method was used to formulate tablets. in vitro dissolution was carried out using usp ii apparatus. result: potential taste masking increased with increasing concentration of resin. indion？ 214 resin showed better taste masking effect as compared to indion？ 234 and indion？ 414. percent of drug loading was maximum at drug : resin ratio of 1:1, after that it decreased. prolonged (upto 5 h) and slow drug release was observed with resin 214 at higher concentration. conclusions: out of three resins chosen, indion？ 214 at higher concentration exhibit excellent taste masking as well as sustained drug release action.