Manifestaciones osteoarticulares por amiloidosis sistémica

amyloidosis is a generic term that refers to the extracellular tissue deposition of fibrils composed of low molecular weight subunits of a variety of proteins. amyloidosis classification depends on its etiology and subtype of protein involved. systemic secondary amyloidosis (aa) is the most frequent subtype seen on rheumatology services because rheumatoid arthritis is currently the most frequent cause of aa, although its incidence has been declined because a better treatment of rheumatoid arthritis with disease-modifying anti-rheumatic drugs (dmard). in this review we provide a general overview of the pathogenesis, clinical manifestations, diagnosis, and treatment of the systemic amyloidosis, emphasizing on the rheu-matic manifestations of these disorders. besides, we present a photographic material obtained in the last 20 years in several rheumatologic centers in our country that it has a crucial role in the diagnosis and follow-up of this infrequent pathology.