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Exposi??o repetida à cafeína aumenta a atividade locomotora induzida pelo femproporex em ratos adolescentes e adultos

DOI: 10.1590/S1516-93322008000300011

Keywords: caffeine, femproporex, locomotor activity [experimental study], psychostimulants.

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Abstract:

caffeine and femproporex are psychostimulants drugs widely consumed in brazil. behavioral sensitization is defined as an augmentation in the behavioral effect of a psychostimulant upon re-administration. repeated administration of a psychostimulant produces behavioral sensitization to that drug and cross-sensitization to other drugs. we investigated whether repeated administration of caffeine increases femproporex-induced locomotor activity in adolescent and adult rats. forty-eight adolescent (postnatal day 27) and 32 adult (postnatal day 60) received i.p. injections of caffeine (caf) (10.0 mg/kg) (adolescent n = 24; adult n = 16)) or saline (adolescent n = 24; adult n = 16) once daily for ten days. three days following the last injection each group was subdivided and received a challenge injection of femproporex (2.0 mg/kg, i.p.) or saline. locomotor activity was recorded for 1 hour in 5 - minute intervals. our results showed that repeated injections of caffeine increased femproporex - induced locomotor activity in adult and adolescent rats.

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